UniProt C9X1G5
CRISPR-associated endonuclease Cas9 (C9X1G5)
CRISPR-associated endonuclease Cas9 (UniProt C9X1G5), EC 3.1.-.-: 18 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 159 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- C9X1G5
- Protein
- CRISPR-associated endonuclease Cas9
- EC
- 3.1.-.-
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 159 · 9 records with a druggable one
Structures
19 records of C9X1G5 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6JDJ | Crystal structure of AcrIIC2 dimer in complex with partial Nme1Cas9 | x-ray diffraction | C | — | 1 (best 0.48) |
| 6JDJ | Crystal structure of ACRIIC2 dimer in complex with partial NME1CAS9 | x-ray diffraction | C | — | — |
| 6JDQ | Crystal structure of Nme1Cas9 in complex with sgRNA | x-ray diffraction | A | — | 20 (best 0.81) |
| 6JDQ | Crystal structure of NME1CAS9 in complex with sgrna | x-ray diffraction | A | — | — |
| 6JDV | Crystal structure of Nme1Cas9 in complex with sgRNA and target DNA (ATATGATT PAM) in catalytic state | x-ray diffraction | A | MG | 20 (best 0.86) |
| 6JDV | Crystal structure of NME1CAS9 in complex with sgrna and target DNA (atatgatt pam) in catalytic state | x-ray diffraction | A | MG | — |
| 6JDX | Crystal structure of AcrIIC2 dimer in complex with partial Nme1Cas9 preprocessed with protease… | x-ray diffraction | C | — | 1 (best 0.54) |
| 6JDX | Crystal structure of ACRIIC2 dimer in complex with partial NME1CAS9 preprocessed with protease… | x-ray diffraction | C | — | — |
| 6JE4 | Crystal structure of Nme1Cas9-sgRNA-dsDNA dimer mediated by double protein inhibitor AcrIIC3… | x-ray diffraction | A, E, K, O | — | 20 (best 0.88) |
| 6JE4 | Crystal structure of NME1CAS9-sgrna-dsdna dimer mediated by double protein inhibitor ACRIIC3… | x-ray diffraction | A, E, K, O | — | — |
| 6JE9 | Crystal structure of Nme1Cas9-sgRNA dimer mediated by double protein inhibitor AcrIIC3 monomers | x-ray diffraction | A, C | — | 20 (best 0.84) |
| 6JE9 | Crystal structure of NME1CAS9-sgrna dimer mediated by double protein inhibitor ACRIIC3 monomers | x-ray diffraction | A, C | — | — |
| 6KC7 | Crystal structure of Nme1Cas9 in complex with sgRNA and target DNA (ATATGATT PAM) in seed-base… | x-ray diffraction | A | — | 20 (best 0.85) |
| 6KC7 | Crystal structure of NME1CAS9 in complex with sgrna and target DNA (atatgatt pam) in seed-base… | x-ray diffraction | A | — | — |
| 6KC8 | Crystal structure of WT Nme1Cas9 in complex with sgRNA and target DNA (ATATGATT PAM) in… | x-ray diffraction | A | — | 20 (best 0.86) |
| 6KC8 | Crystal structure of wt NME1CAS9 in complex with sgrna and target DNA (atatgatt pam) in… | x-ray diffraction | A | — | — |
| 8HJ4 | CryoEM structure of an anti-CRISPR protein AcrIIC5 bound to Nme1Cas9-sgRNA complex | electron microscopy | A | — | 20 (best 0.86) |
| 8JA0 | Cryo-EM structure of the NmeCas9-sgRNA-AcrIIC4 ternary complex | electron microscopy | A | — | 17 (best 0.89) |
| C9X1G5 | AlphaFold monomer V2.0 prediction for CRISPR-associated endonuclease CAS9 (C9X1G5) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 2 records
Experiment against prediction
- 6JE4 chain A against the predicted model C9X1G5: TM-score 0.97, RMSD 1.84 Å
- 6JE4 chain A against the predicted model C9X1G5: TM-score 0.97, RMSD 1.84 Å
- 6JE4 chain O against the predicted model C9X1G5: TM-score 0.97, RMSD 1.89 Å
- 6JE4 chain O against the predicted model C9X1G5: TM-score 0.97, RMSD 1.89 Å
- 6JE4 chain E against the predicted model C9X1G5: TM-score 0.97, RMSD 1.91 Å
- 6JE4 chain E against the predicted model C9X1G5: TM-score 0.97, RMSD 1.91 Å
- 6JE4 chain K against the predicted model C9X1G5: TM-score 0.97, RMSD 1.99 Å
- 6JE4 chain K against the predicted model C9X1G5: TM-score 0.97, RMSD 1.99 Å
- 6KC7 chain A against the predicted model C9X1G5: TM-score 0.94, RMSD 2.68 Å
- 6KC7 chain A against the predicted model C9X1G5: TM-score 0.94, RMSD 2.68 Å
Elsewhere
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