UniProt B9RU15
Probable Histone-lysine N-methyltransferase ATXR5 (B9RU15)
Probable Histone-lysine N-methyltransferase ATXR5 (UniProt B9RU15), EC 2.1.1.43: 10 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 11 pockets. Binding sites, druggability and experiment against…
- UniProt
- B9RU15
- Protein
- Probable Histone-lysine N-methyltransferase ATXR5
- EC
- 2.1.1.43
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 11 · 3 records with a druggable one
Structures
11 records of B9RU15 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4O30 | Crystal structure of ATXR5 in complex with histone H3.1 and AdoHcy | x-ray diffraction | A, B | — | — |
| 4O30 | Crystal structure of ATXR5 in complex with histone H3.1 and adohcy | x-ray diffraction | A, B | — | — |
| 5VA6 | Crystal structure of ATXR5 in complex with histone H3.1 mono-methylated on R26 | x-ray diffraction | A, B | SAH | 4 (best 0.62) |
| 5VA6 | Crystal structure of ATXR5 in complex with histone H3.1 mono- methylated on R26 | x-ray diffraction | A, B | — | — |
| 5VAC | Crystal Structure of ATXR5 SET domain in complex with K36me3 histone H3 peptide | x-ray diffraction | A | SAH | 2 (best 0.64) |
| 5VAC | Crystal structure of ATXR5 set domain in complex with K36ME3 histone H3 peptide | x-ray diffraction | A | — | — |
| 5VAH | Crystal structure of ATXR5 SET domain in complex with histone H3 di-methylated on R26 | x-ray diffraction | A, B | SAH | 5 (best 0.63) |
| 5VAH | Crystal structure of ATXR5 set domain in complex with histone H3 di- methylated on R26 | x-ray diffraction | A, B | — | — |
| 5VBC | Crystal structure of ATXR5 in complex with histone H3.1 | x-ray diffraction | A, B | — | — |
| 5VBC | Crystal structure of ATXR5 in complex with histone H3.1 | x-ray diffraction | A, B | — | — |
| B9RU15 | AlphaFold monomer V2.0 prediction for probable histone-lysine N-methyltransferase ATXR5 (B9RU15) | predicted | A | — | — |
Ligands
- SAH · S-adenosyl-L-homocysteine · in 3 records
Experiment against prediction
- 5VAH chain B against the predicted model B9RU15: TM-score 1.00, RMSD 0.29 Å
- 5VA6 chain A against the predicted model B9RU15: TM-score 1.00, RMSD 0.30 Å
- 5VAH chain A against the predicted model B9RU15: TM-score 1.00, RMSD 0.36 Å
- 5VAC chain A against the predicted model B9RU15: TM-score 1.00, RMSD 0.38 Å
- 5VBC chain A against the predicted model B9RU15: TM-score 0.99, RMSD 0.27 Å
- 5VBC chain A against the predicted model B9RU15: TM-score 0.99, RMSD 0.27 Å
- 5VA6 chain B against the predicted model B9RU15: TM-score 0.99, RMSD 0.50 Å
- 5VAH chain B against the predicted model B9RU15: TM-score 0.99, RMSD 0.29 Å
- 4O30 chain A against the predicted model B9RU15: TM-score 0.99, RMSD 0.30 Å
- 4O30 chain A against the predicted model B9RU15: TM-score 0.99, RMSD 0.30 Å
Elsewhere
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