UniProt B7M1C7

Threonine--tRNA ligase (B7M1C7)

Threonine--tRNA ligase (UniProt B7M1C7), EC 6.1.1.3: 2 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: B7M1C7
Protein: Threonine--tRNA ligase
EC: 6.1.1.3
Experimental structures: 2
Predicted models: 1
Ligands: 3
Pockets: 17 · 3 records with a druggable one

Structures

3 records of B7M1C7 in the MolNFT archive: 2 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
8OU8	Crystal structure of E. coli threonyl tRNA synthetase in complex with a TM84 analogue	x-ray diffraction	D, A	W0U, ZN	6 (best 0.84)
8QIC	Structure-based identification of salicylic acid derivatives as malarial threonyl tRNA-synthetase…	x-ray diffraction	A, D	VL0, ZN	8 (best 0.84)
B7M1C7	AlphaFold monomer V2.0 prediction for threonine--tRNA ligase (B7M1C7)	predicted	A	—	3 (best 0.67)

Ligands

ZN · Zinc ion · in 2 records
VL0 · 2-oxidanyl-5-[[4-(phenylmethyl)phenyl]sulfamoyl]benzoic acid · in 1 record
W0U · [(2~{S},4~{S},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-oxolan-2-yl]methoxy-~{N}-[(2~{S},3~{S})-2-azanyl-3-oxidanyl-butanoyl]phosphonamidic acid · in 1 record

Experiment against prediction

8QIC chain A against the predicted model B7M1C7: TM-score 0.99, RMSD 0.93 Å
8OU8 chain D against the predicted model B7M1C7: TM-score 0.98, RMSD 1.00 Å
8QIC chain D against the predicted model B7M1C7: TM-score 0.98, RMSD 1.09 Å
8OU8 chain A against the predicted model B7M1C7: TM-score 0.98, RMSD 1.12 Å

Elsewhere

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