UniProt B1MHW4
Phosphoribosylaminoimidazole-succinocarboxamide synthase (B1MHW4)
Phosphoribosylaminoimidazole-succinocarboxamide synthase (UniProt B1MHW4), EC 6.3.2.6: 26 experimental structures on GenesisL1, 13 ligands bound, 16 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- B1MHW4
- Protein
- Phosphoribosylaminoimidazole-succinocarboxamide synthase
- EC
- 6.3.2.6
- Experimental structures
- 26
- Predicted models
- 0
- Ligands
- 13
- Pockets
- 16 · 11 records with a druggable one
Structures
26 records of B1MHW4 in the MolNFT archive: 26 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3R9R | Structure of a Phosphoribosylaminoimidazole-succinocarboxamide synthase from Mycobacterium… | x-ray diffraction | A | — | — |
| 3R9R | Structure of a phosphoribosylaminoimidazole-succinocarboxamide synthase from mycobacterium… | x-ray diffraction | A | — | — |
| 6YVQ | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in apo form | x-ray diffraction | A | SO4 | 2 (best 0.65) |
| 6YVQ | Crystal structure of saicar synthetase (purc) from mycobacterium abscessus in apo form | x-ray diffraction | A | SO4 | — |
| 6YX3 | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with ATP | x-ray diffraction | A | SO4, MG, ATP | 1 (best 0.69) |
| 6YX3 | Crystal structure of saicar synthetase (purc) from mycobacterium abscessus in complex with ATP | x-ray diffraction | A | SO4, MG, ATP | — |
| 6YY6 | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with inhibitor | x-ray diffraction | A | SO4, Q0W | 1 (best 0.70) |
| 6YY6 | Crystal structure of saicar synthetase (purc) from mycobacterium abscessus in complex with inhibitor | x-ray diffraction | A | SO4, Q0W | — |
| 6YY7 | Crystal structure of saicar synthetase (purc) from mycobacterium abscessus in complex with inhibitor | x-ray diffraction | A | Q0T, SO4 | — |
| 6YY8 | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with inhibitor | x-ray diffraction | A | Q0N, SO4 | 1 (best 0.69) |
| 6YY8 | Crystal structure of saicar synthetase (purc) from mycobacterium abscessus in complex with inhibitor | x-ray diffraction | A | Q0N, SO4 | — |
| 6YY9 | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with inhibitor | x-ray diffraction | A | Q0E, SO4 | 2 (best 0.69) |
| 6YY9 | Crystal structure of saicar synthetase (purc) from mycobacterium abscessus in complex with inhibitor | x-ray diffraction | A | Q0E, SO4 | — |
| 6YYA | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with inhibitor | x-ray diffraction | A | PZK, SO4 | 2 (best 0.67) |
| 6YYA | Crystal structure of saicar synthetase (purc) from mycobacterium abscessus in complex with inhibitor | x-ray diffraction | A | PZK, SO4 | — |
| 6YYB | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with inhibitor | x-ray diffraction | A | Q0Q, SO4 | 2 (best 0.65) |
| 6YYB | Crystal structure of saicar synthetase (purc) from mycobacterium abscessus in complex with inhibitor | x-ray diffraction | A | Q0Q, SO4 | — |
| 6YYC | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with inhibitor | x-ray diffraction | A | Q0Z, SO4 | 1 (best 0.71) |
| 6YYC | Crystal structure of saicar synthetase (purc) from mycobacterium abscessus in complex with inhibitor | x-ray diffraction | A | Q0Z, SO4 | — |
| 6YYD | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with inhibitor | x-ray diffraction | A | Q0H, SO4 | 1 (best 0.70) |
| 6YYD | Crystal structure of saicar synthetase (purc) from mycobacterium abscessus in complex with inhibitor | x-ray diffraction | A | Q0H, SO4 | — |
| 6Z0Q | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with fragment… | x-ray diffraction | A | Q4K, SO4 | 2 (best 0.70) |
| 6Z0Q | Crystal structure of saicar synthetase (purc) from mycobacterium abscessus in complex with fragment… | x-ray diffraction | A | Q4K, SO4 | — |
| 6Z0R | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with fragment… | x-ray diffraction | A | Q4H, SO4 | 1 (best 0.68) |
| 6Z0R | Crystal structure of saicar synthetase (purc) from mycobacterium abscessus in complex with fragment… | x-ray diffraction | A | Q4H, SO4 | — |
| B1MHW4 | AlphaFold monomer V2.0 prediction for phosphoribosylaminoimidazole- succinocarboxamide synthase… | — | — | — |
Ligands
- SO4 · Sulfate ion · in 23 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- MG · Magnesium ion · in 2 records
- PZK · 4-azanyl-6-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]pyrimidine-5-carbonitrile · in 2 records
- Q0E · 4-azanyl-6-[1-(pyridin-3-ylmethyl)pyrazol-4-yl]pyrimidine-5-carbonitrile · in 2 records
- Q0H · 4-azanyl-6-[1-[[3,4-bis(fluoranyl) phenyl]methyl]pyrazol-4-yl]pyrimidine-5-carbonitrile · in 2 records
- Q0N · 4-azanyl-6-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]pyrimidine-5-carbonitrile · in 2 records
- Q0Q · 4-azanyl-6-[1-[(1~{R})-1-phenylethyl]pyrazol-4-yl]pyrimidine-5-carbonitrile · in 2 records
- Q0W · 4-azanyl-6-(1-ethylpyrazol-4-yl)pyrimidine-5-carbonitrile · in 2 records
- Q0Z · 5-chloranyl-6-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]pyrimidin-4-amine · in 2 records
- Q4H · 4-azanylpyrimidine-5-carbonitrile · in 2 records
- Q4K · ethyl (2~{S},3~{R})-3-(5-bromanylpyridin-2-yl)-2-fluoranyl-3-oxidanyl-propanoate · in 2 records
- Q0T · Ethyl 2-[4-(6-azanyl-5-cyano-pyrimidin-4-yl)pyrazol-1-yl]ethanoate · in 1 record
Elsewhere
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