UniProt A7ZUK2
DNA-directed RNA polymerase subunit beta' (A7ZUK2)
DNA-directed RNA polymerase subunit beta' (UniProt A7ZUK2), EC 2.7.7.6: 21 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 269 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- A7ZUK2
- Protein
- DNA-directed RNA polymerase subunit beta'
- EC
- 2.7.7.6
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 269 · 22 records with a druggable one
Structures
22 records of A7ZUK2 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4XSX | Crystal structure of CBR 703 bound to Escherichia coli RNA polymerase holoenzyme | x-ray diffraction | D, J | 42S, MG, ZN | 12 (best 0.83) |
| 4XSX | Crystal structure of cbr 703 bound to escherichia COLI RNA polymerase holoenzyme | x-ray diffraction | D, J | 42S, MG, ZN | 12 (best 0.83) |
| 4XSY | Crystal structure of CBR 9379 bound to Escherichia coli RNA polymerase holoenzyme | x-ray diffraction | D, J | 42T, MG, ZN | 10 (best 0.83) |
| 4XSY | Crystal structure of cbr 9379 bound to escherichia COLI RNA polymerase holoenzyme | x-ray diffraction | D, J | 42T, MG, ZN | 10 (best 0.83) |
| 4XSZ | Crystal structure of CBR 9393 bound to Escherichia coli RNA polymerase holoenzyme | x-ray diffraction | D, J | 42U, MG, ZN | 13 (best 0.82) |
| 4XSZ | Crystal structure of cbr 9393 bound to escherichia COLI RNA polymerase holoenzyme | x-ray diffraction | D, J | 42U, MG, ZN | 13 (best 0.82) |
| 4YFK | Escherichia coli RNA polymerase in complex with squaramide compound 8. | x-ray diffraction | D, J | MG, ZN, 4C6 | 9 (best 0.83) |
| 4YFK | Escherichia COLI RNA polymerase in complex with squaramide compound 8. | x-ray diffraction | D, J | MG, ZN, 4C6 | 9 (best 0.83) |
| 4YFN | Escherichia coli RNA polymerase in complex with squaramide compound 14… | x-ray diffraction | D, J | MG, ZN, 4C2 | 11 (best 0.84) |
| 4YFN | Escherichia COLI RNA polymerase in complex with squaramide compound 14… | x-ray diffraction | D, J | MG, ZN, 4C2 | 11 (best 0.84) |
| 4YFX | Escherichia coli RNA polymerase in complex with Myxopyronin B | x-ray diffraction | D, J | MG, ZN, 4C4 | 9 (best 0.86) |
| 4YFX | Escherichia COLI RNA polymerase in complex with myxopyronin B | x-ray diffraction | D, J | MG, ZN, 4C4 | 9 (best 0.86) |
| 4YLN | E. coli Transcription Initiation Complex - 17-bp spacer and 4-nt RNA | x-ray diffraction | D, J, P | ZN, MG | 15 (best 0.87) |
| 4YLN | E. COLI transcription initiation complex - 17-bp spacer and 4-nt RNA | x-ray diffraction | D, J, P | ZN, MG | 15 (best 0.87) |
| 4YLO | E. coli Transcription Initiation Complex - 16-bp spacer and 4-nt RNA | x-ray diffraction | D, J, P | MG, ZN | 15 (best 0.86) |
| 4YLO | E. COLI transcription initiation complex - 16-bp spacer and 4-nt RNA | x-ray diffraction | D, J, P | MG, ZN | 15 (best 0.86) |
| 4YLP | E. coli Transcription Initiation Complex - 16-bp spacer and 5-nt RNA | x-ray diffraction | D, J, P | ZN, MG | 12 (best 0.87) |
| 4YLP | E. COLI transcription initiation complex - 16-bp spacer and 5-nt RNA | x-ray diffraction | D, J, P | ZN, MG | 12 (best 0.87) |
| 8G1S | Cryo-EM structure of 3DVA component 1 of Escherichia coli que-PEC (paused elongation complex) RNA… | electron microscopy | J | MG | 14 (best 0.85) |
| 8G7E | Cryo-EM structure of 3DVA component 0 of Escherichia coli que-PEC (paused elongation complex) RNA… | electron microscopy | J | MG | 13 (best 0.83) |
| 9DR1 | E. coli RNA polymerase consensus volume with a bound fluoride riboswitch in the ligand-bound state | electron microscopy | J | MG | 13 (best 0.84) |
| A7ZUK2 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit beta' (A7ZUK2) | predicted | A | — | 17 (best 0.78) |
Ligands
- MG · Magnesium ion · in 21 records
- ZN · Zinc ion · in 18 records
- 42S · N'-hydroxy-N-phenyl-3-(trifluoromethyl)benzenecarboximidamide · in 2 records
- 42T · 3-{[(2,6-dichlorophenyl)carbamoyl]amino}-N-hydroxy-N'-phenyl-5-(trifluoromethyl)benzenecarboximidamide · in 2 records
- 42U · 4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-N-[2-(piperazin-1-yl)ethyl]-2-(trifluoromethyl)aniline · in 2 records
- 4C2 · N-[3,4-dioxo-2-(4-{[4-(trifluoromethyl)benzyl]amino}piperidin-1-yl)cyclobut-1-en-1-yl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide · in 2 records
- 4C4 · Myxopyronin B · in 2 records
- 4C6 · 3,5-dimethyl-N-{2-[4-(4-methylbenzyl)piperidin-1-yl]-3,4-dioxocyclobut-1-en-1-yl}-1,2-oxazole-4-sulfonamide · in 2 records
Experiment against prediction
- 4YFK chain J against the predicted model A7ZUK2: TM-score 0.98, RMSD 1.63 Å
- 4YFK chain J against the predicted model A7ZUK2: TM-score 0.98, RMSD 1.63 Å
- 4YFN chain J against the predicted model A7ZUK2: TM-score 0.98, RMSD 1.64 Å
- 4YFN chain J against the predicted model A7ZUK2: TM-score 0.98, RMSD 1.64 Å
- 4YFX chain J against the predicted model A7ZUK2: TM-score 0.98, RMSD 1.68 Å
- 4YFX chain J against the predicted model A7ZUK2: TM-score 0.98, RMSD 1.68 Å
- 4YFX chain D against the predicted model A7ZUK2: TM-score 0.98, RMSD 1.84 Å
- 4YFX chain D against the predicted model A7ZUK2: TM-score 0.98, RMSD 1.84 Å
- 4YFN chain D against the predicted model A7ZUK2: TM-score 0.97, RMSD 1.91 Å
- 4YFN chain D against the predicted model A7ZUK2: TM-score 0.97, RMSD 1.91 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.