UniProt A7ZSI4
DNA-directed RNA polymerase subunit alpha (A7ZSI4)
DNA-directed RNA polymerase subunit alpha (UniProt A7ZSI4), EC 2.7.7.6: 18 experimental structures and 1 predicted model on GenesisL1, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- A7ZSI4
- Protein
- DNA-directed RNA polymerase subunit alpha
- EC
- 2.7.7.6
- Experimental structures
- 18
- Predicted models
- 1
- Pockets
- 12 · 1 record with a druggable one
Structures
19 records of A7ZSI4 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4XSX | Crystal structure of CBR 703 bound to Escherichia coli RNA polymerase holoenzyme | x-ray diffraction | A, B, G, H | — | — |
| 4XSX | Crystal structure of cbr 703 bound to escherichia COLI RNA polymerase holoenzyme | x-ray diffraction | A, B, G, H | — | — |
| 4XSY | Crystal structure of CBR 9379 bound to Escherichia coli RNA polymerase holoenzyme | x-ray diffraction | A, B, G, H | — | 10 (best 0.83) |
| 4XSY | Crystal structure of cbr 9379 bound to escherichia COLI RNA polymerase holoenzyme | x-ray diffraction | A, B, G, H | — | — |
| 4XSZ | Crystal structure of CBR 9393 bound to Escherichia coli RNA polymerase holoenzyme | x-ray diffraction | A, B, G, H | — | — |
| 4XSZ | Crystal structure of cbr 9393 bound to escherichia COLI RNA polymerase holoenzyme | x-ray diffraction | A, B, G, H | — | — |
| 4YFK | Escherichia coli RNA polymerase in complex with squaramide compound 8. | x-ray diffraction | A, B, G, H | — | — |
| 4YFK | Escherichia COLI RNA polymerase in complex with squaramide compound 8. | x-ray diffraction | A, B, G, H | — | — |
| 4YFN | Escherichia coli RNA polymerase in complex with squaramide compound 14… | x-ray diffraction | A, B, G, H | — | — |
| 4YFN | Escherichia COLI RNA polymerase in complex with squaramide compound 14… | x-ray diffraction | A, B, G, H | — | — |
| 4YFX | Escherichia coli RNA polymerase in complex with Myxopyronin B | x-ray diffraction | A, B, G, H | — | — |
| 4YFX | Escherichia COLI RNA polymerase in complex with myxopyronin B | x-ray diffraction | A, B, G, H | — | — |
| 4YLN | E. coli Transcription Initiation Complex - 17-bp spacer and 4-nt RNA | x-ray diffraction | A, B, G, H, M, N | — | — |
| 4YLN | E. COLI transcription initiation complex - 17-bp spacer and 4-nt RNA | x-ray diffraction | A, B, G, H, M, N | — | — |
| 4YLO | E. coli Transcription Initiation Complex - 16-bp spacer and 4-nt RNA | x-ray diffraction | A, B, G, H, M, N | — | — |
| 4YLO | E. COLI transcription initiation complex - 16-bp spacer and 4-nt RNA | x-ray diffraction | A, B, G, H, M, N | — | — |
| 4YLP | E. coli Transcription Initiation Complex - 16-bp spacer and 5-nt RNA | x-ray diffraction | A, B, G, H, M, N | — | — |
| 4YLP | E. COLI transcription initiation complex - 16-bp spacer and 5-nt RNA | x-ray diffraction | A, B, G, H, M, N | — | — |
| A7ZSI4 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (A7ZSI4) | predicted | A | — | 2 (best 0.41) |
Experiment against prediction
- 4YFK chain B against the predicted model A7ZSI4: TM-score 0.96, RMSD 1.19 Å
- 4YFK chain B against the predicted model A7ZSI4: TM-score 0.96, RMSD 1.19 Å
- 4YLN chain B against the predicted model A7ZSI4: TM-score 0.96, RMSD 1.25 Å
- 4YLN chain B against the predicted model A7ZSI4: TM-score 0.96, RMSD 1.25 Å
- 4XSZ chain H against the predicted model A7ZSI4: TM-score 0.96, RMSD 1.19 Å
- 4XSZ chain H against the predicted model A7ZSI4: TM-score 0.96, RMSD 1.19 Å
- 4XSX chain H against the predicted model A7ZSI4: TM-score 0.96, RMSD 1.39 Å
- 4XSX chain H against the predicted model A7ZSI4: TM-score 0.96, RMSD 1.39 Å
- 4XSY chain H against the predicted model A7ZSI4: TM-score 0.96, RMSD 1.39 Å
- 4XSY chain H against the predicted model A7ZSI4: TM-score 0.96, RMSD 1.39 Å
Elsewhere
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