UniProt A7WYM2
Thymidylate kinase (A7WYM2)
Thymidylate kinase (UniProt A7WYM2), EC 2.7.4.9: 2 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- A7WYM2
- Protein
- Thymidylate kinase
- EC
- 2.7.4.9
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 3 · 1 record with a druggable one
Structures
3 records of A7WYM2 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4XWA | TMK from S.aureus in complex with the Piperidinyl Thymine class inhibitor with a C5 ethyl-amine | x-ray diffraction | A, B | 43N | 3 (best 0.76) |
| 4XWA | Tmk from S.AUREUS in complex with the piperidinyl thymine class inhibitor with a C5 ethyl-amine | x-ray diffraction | A, B | — | — |
| A7WYM2 | AlphaFold monomer V2.0 prediction for thymidylate kinase (A7WYM2) | predicted | A | — | — |
Ligands
- 43N · 2-(3-chlorophenoxy)-6-(ethylamino)-4-[(R)-[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl](phenyl)methyl]benzoic acid · in 1 record
Experiment against prediction
- 4XWA chain B against the predicted model A7WYM2: TM-score 0.95, RMSD 1.41 Å
- 4XWA chain B against the predicted model A7WYM2: TM-score 0.95, RMSD 1.41 Å
- 4XWA chain A against the predicted model A7WYM2: TM-score 0.94, RMSD 1.59 Å
- 4XWA chain A against the predicted model A7WYM2: TM-score 0.94, RMSD 1.59 Å
Elsewhere
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