UniProt A7UX13

Hercynylcysteine sulfoxide lyase (A7UX13)

Hercynylcysteine sulfoxide lyase (UniProt A7UX13), EC 4.4.1.-: 5 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…

UniProt: A7UX13
Protein: Hercynylcysteine sulfoxide lyase
EC: 4.4.1.-
Experimental structures: 5
Predicted models: 1
Ligands: 2
Pockets: 20 · 1 record with a druggable one

Structures

6 records of A7UX13 in the MolNFT archive: 5 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
5UTS	Carbon sulfoxide lyase, EGT2 in the ergothioneine biosynthesis pathway	x-ray diffraction	G, C, H, D, E, F, B, A	—	—
5V12	Crystal structure of Carbon Sulfoxide lyase, Egt2 Y134F with sulfenic acid intermediate	x-ray diffraction	E, G, F, H, C, D, A, B	8QJ	—
5V12	Crystal structure of carbon sulfoxide lyase, EGT2 Y134F with sulfenic acid intermediate	x-ray diffraction	E, G, F, H, C, D, A, B	8QJ	—
5V1X	Carbon Sulfoxide lyase, Egt2 Y134F in complex with its substrate	x-ray diffraction	E, F, D, C, A, B, G, H	8VV	20 (best 0.84)
5V1X	Carbon sulfoxide lyase, EGT2 Y134F in complex with its substrate	x-ray diffraction	E, F, D, C, A, B, G, H	8VV	—
A7UX13	AlphaFold monomer V2.0 prediction for hercynylcysteine sulfoxide lyase (A7UX13)	predicted	A	—	—

Ligands

8QJ · (2~{S})-3-(2-oxidanylsulfanyl-1~{H}-imidazol-4-yl)-2-(trimethyl-$L^{4}-azanyl)propanoic acid · in 2 records
8VV · (2~{S})-3-[2-[(2~{R})-2-azanyl-3-oxidanyl-3-oxidanylidene-propyl]sulfinyl-1~{H}-imidazol-4-yl]-2-(trimethyl-$L^{4}-azanyl)propanoic acid · in 2 records

Experiment against prediction

5V1X chain E against the predicted model A7UX13: TM-score 1.00, RMSD 0.23 Å
5V1X chain E against the predicted model A7UX13: TM-score 1.00, RMSD 0.23 Å
5UTS chain B against the predicted model A7UX13: TM-score 1.00, RMSD 0.27 Å
5UTS chain H against the predicted model A7UX13: TM-score 1.00, RMSD 0.28 Å
5V12 chain E against the predicted model A7UX13: TM-score 1.00, RMSD 0.28 Å
5V12 chain E against the predicted model A7UX13: TM-score 1.00, RMSD 0.28 Å
5UTS chain C against the predicted model A7UX13: TM-score 1.00, RMSD 0.29 Å
5UTS chain E against the predicted model A7UX13: TM-score 1.00, RMSD 0.30 Å
5V12 chain H against the predicted model A7UX13: TM-score 1.00, RMSD 0.30 Å
5V12 chain H against the predicted model A7UX13: TM-score 1.00, RMSD 0.30 Å

Elsewhere

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