UniProt A7B1V0

Pyridoxal-dependent decarboxylase domain protein (A7B1V0)

Pyridoxal-dependent decarboxylase domain protein (UniProt A7B1V0): 4 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 84 pockets. Binding sites, druggability and experiment against prediction…

UniProt: A7B1V0
Protein: Pyridoxal-dependent decarboxylase domain protein
Experimental structures: 4
Predicted models: 1
Ligands: 3
Pockets: 84 · 5 records with a druggable one

Structures

5 records of A7B1V0 in the MolNFT archive: 4 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4OBU	Ruminococcus gnavus tryptophan decarboxylase RUMGNA_01526 (apo)	x-ray diffraction	E, A, U, G, H, F, B, C	PLP	20 (best 0.83)
4OBU	Ruminococcus gnavus tryptophan decarboxylase RUMGNA_01526 (apo)	x-ray diffraction	E, A, U, G, H, F, B, C	PLP	20 (best 0.83)
4OBV	Ruminococcus gnavus tryptophan decarboxylase RUMGNA_01526 (alpha-FMT)	x-ray diffraction	D, C, B, A	2SU, 3SO	20 (best 0.83)
4OBV	Ruminococcus gnavus tryptophan decarboxylase RUMGNA_01526 (alpha-fmt)	x-ray diffraction	D, C, B, A	2SU, 3SO	20 (best 0.83)
A7B1V0	AlphaFold monomer V2.0 prediction for tryptophan decarboxylase (A7B1V0)	predicted	A	—	4 (best 0.56)

Ligands

2SU · alpha-(fluoromethyl)-D-tryptophan · in 2 records
3SO · {5-hydroxy-4-[(1E)-4-(1H-indol-3-yl)-3-oxobut-1-en-1-yl]-6-methylpyridin-3-yl}methyl dihydrogen phosphate · in 2 records
PLP · Pyridoxal-5'-phosphate · in 2 records

Experiment against prediction

4OBV chain B against the predicted model A7B1V0: TM-score 0.99, RMSD 0.55 Å
4OBV chain B against the predicted model A7B1V0: TM-score 0.99, RMSD 0.55 Å
4OBV chain D against the predicted model A7B1V0: TM-score 0.99, RMSD 0.56 Å
4OBV chain D against the predicted model A7B1V0: TM-score 0.99, RMSD 0.56 Å
4OBV chain C against the predicted model A7B1V0: TM-score 0.99, RMSD 0.57 Å
4OBV chain C against the predicted model A7B1V0: TM-score 0.99, RMSD 0.57 Å
4OBU chain E against the predicted model A7B1V0: TM-score 0.97, RMSD 1.57 Å
4OBU chain E against the predicted model A7B1V0: TM-score 0.97, RMSD 1.57 Å

Elsewhere

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