UniProt A5U4D6
Proteasome subunit beta (A5U4D6)
Proteasome subunit beta (UniProt A5U4D6), EC 3.4.25.1: 16 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 82 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- A5U4D6
- Protein
- Proteasome subunit beta
- EC
- 3.4.25.1
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 82 · 4 records with a druggable one
Structures
17 records of A5U4D6 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5THO | Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with N,C-capped Dipeptide… | x-ray diffraction | H, I, J, K, L, M, N, V, W, X, Y, Z, a, b | 7C7 | 20 (best 0.84) |
| 5THO | Crystal structure of mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide… | x-ray diffraction | H, I, J, K, L, M, N, V, W, X, Y, Z, a, b | 7C7 | — |
| 5TRG | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide DPLG-2 | x-ray diffraction | H, I, J, K, L, M, N, V, W, X, Y, Z, a, b | 7HJ | — |
| 5TRG | Structure of mycobacterium tuberculosis proteasome in complex with N, C-capped dipeptide dplg-2 | x-ray diffraction | H, I, J, K, L, M, N, V, W, X, Y, Z, a, b | 7HJ | — |
| 5TRR | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2169 | x-ray diffraction | H, I, J, K, L, M, N, V, W, X, Y, Z, a, b | 7HY | — |
| 5TRR | Structure of mycobacterium tuberculosis proteasome in complex with N, C-capped dipeptide PKS2169 | x-ray diffraction | H, I, J, K, L, M, N, V, W, X, Y, Z, a, b | 7HY | — |
| 5TRS | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2144 | x-ray diffraction | H, I, J, K, L, M, N, V, W, X, Y, Z, a, b | 7HZ | 20 (best 0.85) |
| 5TRS | Structure of mycobacterium tuberculosis proteasome in complex with N, C-capped dipeptide PKS2144 | x-ray diffraction | H, I, J, K, L, M, N, V, W, X, Y, Z, a, b | 7HZ | — |
| 5TRY | Structure of mycobacterium tuberculosis proteasome in complex with N, C-capped dipeptide PKS2206 | x-ray diffraction | H, I, J, K, L, M, N, V, W, X, Y, Z, a, b | 7J0 | — |
| 5TS0 | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2208 | x-ray diffraction | H, I, J, K, L, M, N, V, W, X, Y, Z, a, b | 7J1 | 20 (best 0.83) |
| 5TS0 | Structure of mycobacterium tuberculosis proteasome in complex with N, C-capped dipeptide PKS2208 | x-ray diffraction | H, I, J, K, L, M, N, V, W, X, Y, Z, a, b | 7J1 | — |
| 6BGL | Doubly PafE-capped 20S core particle in Mycobacterium tuberculosis | electron microscopy | P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c | — | 20 (best 0.81) |
| 6BGL | Doubly pafe-capped 20S core particle in mycobacterium tuberculosis | electron microscopy | P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c | — | — |
| 6BGO | Singly PafE-capped 20S CP in Mycobacterium tuberculosis | electron microscopy | P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c | — | — |
| 6BGO | Singly pafe-capped 20S cp in mycobacterium tuberculosis | electron microscopy | P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c | — | — |
| 6WNK | Macrocyclic peptides TDI5575 that selectively inhibit the mycobacterium tuberculosis proteasome | x-ray diffraction | H, I, J, K, L, M, N, V, W, X, Y, Z, a, b | U5Y | — |
| A5U4D6 | AlphaFold monomer V2.0 prediction for proteasome subunit beta (A5U4D6) | predicted | A | — | 2 (best 0.50) |
Ligands
- 7C7 · N,N-diethyl-N~2~-(3-phenylpropanoyl)-L-asparaginyl-O-methyl-N-[(naphthalen-1-yl)methyl]-L-serinamide · in 2 records
- 7HJ · N,N-diethyl-N~2~-[(2E)-3-phenylprop-2-enoyl]-L-asparaginyl-4-fluoro-N-[(naphthalen-1-yl)methyl]-L-phenylalaninamide · in 2 records
- 7HY · N,N-diethyl-N~2~-(3-phenylpropanoyl)-L-asparaginyl-N-[(naphthalen-1-yl)methyl]-L-alaninamide · in 2 records
- 7HZ · N-tert-butoxy-N~2~-(5-methyl-1,2-oxazole-3-carbonyl)-L-asparaginyl-O-methyl-N-[(naphthalen-1-yl)methyl]-L-serinamide · in 2 records
- 7J1 · (2S)-N-{(2S)-3-methoxy-1-[(naphthalen-1-ylmethyl) amino]-1-oxopropan-2-yl}-4-oxo-2-[(3-phenylpropanoyl) amino]-4-(1H-pyrrol-1-yl)butanamide (non-preferred name) · in 2 records
- 7J0 · (2~{S})-~{N}-[(2~{S})-3-methoxy-1-(naphthalen-1-ylmethylamino)-1-oxidanylidene-propan-2-yl]-4-oxidanylidene-2-(3-phenylpropanoylamino)-4-piperidin-1-yl-butanamide · in 1 record
- U5Y · (12S,15S)-N-[(2-fluorophenyl)methyl]-10,13-dioxo-12-{2-oxo-2-[(2R)-2-phenylpyrrolidin-1-yl]ethyl}-2-oxa-11, 14-diazatricyclo[15.2.2.1~3,7~]docosa-1(19),3(22),4,6, 17,20-hexaene-15-carboxamide · in 1 record
Experiment against prediction
- 5TRS chain W against the predicted model A5U4D6: TM-score 1.00, RMSD 0.33 Å
- 5THO chain a against the predicted model A5U4D6: TM-score 1.00, RMSD 0.34 Å
- 6WNK chain K against the predicted model A5U4D6: TM-score 1.00, RMSD 0.34 Å
- 5THO chain W against the predicted model A5U4D6: TM-score 1.00, RMSD 0.34 Å
- 5TRS chain H against the predicted model A5U4D6: TM-score 1.00, RMSD 0.35 Å
- 5TRS chain H against the predicted model A5U4D6: TM-score 1.00, RMSD 0.35 Å
- 5TS0 chain L against the predicted model A5U4D6: TM-score 1.00, RMSD 0.35 Å
- 5THO chain I against the predicted model A5U4D6: TM-score 1.00, RMSD 0.35 Å
- 5TRR chain H against the predicted model A5U4D6: TM-score 1.00, RMSD 0.35 Å
- 5TRR chain H against the predicted model A5U4D6: TM-score 1.00, RMSD 0.35 Å
Elsewhere
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