UniProt A1L314
Macrophage-expressed gene 1 protein (A1L314)
Macrophage-expressed gene 1 protein (UniProt A1L314): 9 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 108 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- A1L314
- Protein
- Macrophage-expressed gene 1 protein
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 108 · 6 records with a druggable one
Structures
10 records of A1L314 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6SB1 | Crystal structure of murine perforin-2 P2 domain crystal form 1 | x-ray diffraction | A, B | CL | — |
| 6SB3 | CryoEM structure of murine perforin-2 ectodomain in a pre-pore form | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | NAG | 20 (best 0.90) |
| 6SB3 | Cryoem structure of murine perforin-2 ectodomain in a pre-pore form | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | NAG | — |
| 6SB4 | Crystal structure of murine perforin-2 P2 domain crystal form 2 | x-ray diffraction | A, B, C, D, E, F, G, H | — | 20 (best 0.80) |
| 6SB4 | Crystal structure of murine perforin-2 P2 domain crystal form 2 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 6SB5 | CryoEM structure of murine perforin-2 ectodomain in a pore form | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | NAG | 20 (best 0.81) |
| 6SB5 | Cryoem structure of murine perforin-2 ectodomain in a pore form | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | NAG | — |
| 8A1D | Structure of murine perforin-2 (Mpeg1) pore in ring form | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | NAG, MA4 | 20 (best 0.83) |
| 8A1S | Structure of murine perforin-2 (Mpeg1) pore in twisted form | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | NAG | 20 (best 0.86) |
| A1L314 | AlphaFold monomer V2.0 prediction for macrophage-expressed gene 1 protein (A1L314) | predicted | A | — | 8 (best 0.66) |
Ligands
Experiment against prediction
- 6SB4 chain H against the predicted model A1L314: TM-score 0.97, RMSD 0.92 Å
- 6SB4 chain H against the predicted model A1L314: TM-score 0.97, RMSD 0.92 Å
- 6SB4 chain G against the predicted model A1L314: TM-score 0.96, RMSD 1.20 Å
- 6SB4 chain G against the predicted model A1L314: TM-score 0.96, RMSD 1.20 Å
- 6SB4 chain A against the predicted model A1L314: TM-score 0.96, RMSD 1.21 Å
- 6SB4 chain A against the predicted model A1L314: TM-score 0.96, RMSD 1.21 Å
- 6SB4 chain C against the predicted model A1L314: TM-score 0.95, RMSD 1.24 Å
- 6SB4 chain C against the predicted model A1L314: TM-score 0.95, RMSD 1.24 Å
- 6SB3 chain D against the predicted model A1L314: TM-score 0.95, RMSD 1.85 Å
- 6SB3 chain O against the predicted model A1L314: TM-score 0.95, RMSD 1.85 Å
Elsewhere
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