UniProt A0R5D9
DNA topoisomerase 1 (A0R5D9)
DNA topoisomerase 1 (UniProt A0R5D9), EC 5.6.2.2: 2 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- A0R5D9
- Protein
- DNA topoisomerase 1
- EC
- 5.6.2.2
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 27 · 2 records with a druggable one
Structures
3 records of A0R5D9 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6PCM | Crystal Structure of Mycobacterium smegmatis Topoisomerase I with ssDNA bound to both N- and… | x-ray diffraction | A, B | SO4 | 20 (best 0.80) |
| 6PCM | Crystal structure of mycobacterium smegmatis topoisomerase I with ssdna bound to both N- and… | x-ray diffraction | A, B | SO4 | — |
| A0R5D9 | AlphaFold monomer V2.0 prediction for DNA topoisomerase 1 (A0R5D9) | predicted | A | — | 7 (best 0.72) |
Ligands
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 6PCM chain B against the predicted model A0R5D9: TM-score 0.84, RMSD 2.78 Å
- 6PCM chain B against the predicted model A0R5D9: TM-score 0.84, RMSD 2.78 Å
- 6PCM chain A against the predicted model A0R5D9: TM-score 0.83, RMSD 2.78 Å
- 6PCM chain A against the predicted model A0R5D9: TM-score 0.83, RMSD 2.78 Å
Elsewhere
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