UniProt A0QWG5
Phosphatidylinositol mannoside acyltransferase (A0QWG5)
Phosphatidylinositol mannoside acyltransferase (UniProt A0QWG5), EC 2.3.1.-, 2.3.1.265: 12 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 17 pockets. Binding sites, druggability and experiment…
- UniProt
- A0QWG5
- Protein
- Phosphatidylinositol mannoside acyltransferase
- EC
- 2.3.1.-, 2.3.1.265
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 17 · 3 records with a druggable one
Structures
13 records of A0QWG5 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5F2T | Crystal structure of membrane associated PatA from Mycobacterium smegmatis in complex with… | x-ray diffraction | A, B | PLM, MG | — |
| 5F2T | Crystal structure of membrane associated pata from mycobacterium smegmatis in complex with… | x-ray diffraction | A, B | — | — |
| 5F2Z | Crystal structure of membrane associated PatA from Mycobacterium smegmatis in complex with… | x-ray diffraction | A, B, C, D | PLM | — |
| 5F2Z | Crystal structure of membrane associated pata from mycobacterium smegmatis in complex with… | x-ray diffraction | A, B, C, D | — | — |
| 5F31 | Crystal structure of membrane associated PatA from Mycobacterium smegmatis in complex with… | x-ray diffraction | A | PLM, NA | 1 (best 0.76) |
| 5F31 | Crystal structure of membrane associated pata from mycobacterium smegmatis in complex with… | x-ray diffraction | A | — | — |
| 5F34 | Crystal structure of membrane associated PatA from Mycobacterium smegmatis in complex with… | x-ray diffraction | A, B, C, D | HD6 | — |
| 5F34 | Crystal structure of membrane associated pata from mycobacterium smegmatis in complex with… | x-ray diffraction | A, B, C, D | — | — |
| 5OCE | THE MOLECULAR MECHANISM OF SUBSTRATE RECOGNITION AND CATALYSIS OF THE MEMBRANE ACYLTRANSFERASE PatA… | x-ray diffraction | A, B, C, D | PLM, BMA, 9R2 | 7 (best 0.82) |
| 5OCE | The molecular mechanism of substrate recognition and catalysis of the membrane acyltransferase pata… | x-ray diffraction | A, B, C, D | PLM, BMA, 9R2 | — |
| 7OJT | Crystal structure of unliganded PatA, a membrane associated acyltransferase from Mycobacterium… | x-ray diffraction | A, B, C, D | — | 9 (best 0.77) |
| 7OJT | Crystal structure of unliganded pata, a membrane associated acyltransferase from mycobacterium… | x-ray diffraction | A, B, C, D | — | — |
| A0QWG5 | AlphaFold monomer V2.0 prediction for phosphatidylinositol mannoside acyltransferase (A0QWG5) | predicted | A | — | — |
Ligands
- PLM · Palmitic acid · in 5 records
- 9R2 · [(2~{R},3~{S},4~{S},5~{S},6~{S})-3,4,5,6-tetrakis(oxidanyl)oxan-2-yl]methyl hexadecanoate · in 2 records
- BMA · beta-D-mannopyranose · in 2 records
- HD6 · [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{S})-4-[[3-(2-hexadecylsulfanylethylamino)-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate · in 1 record
- MG · Magnesium ion · in 1 record
- NA · Sodium ion · in 1 record
Experiment against prediction
- 5F34 chain A against the predicted model A0QWG5: TM-score 0.99, RMSD 0.43 Å
- 5F34 chain A against the predicted model A0QWG5: TM-score 0.99, RMSD 0.43 Å
- 5F34 chain C against the predicted model A0QWG5: TM-score 0.99, RMSD 0.43 Å
- 5F34 chain C against the predicted model A0QWG5: TM-score 0.99, RMSD 0.43 Å
- 5F34 chain D against the predicted model A0QWG5: TM-score 0.99, RMSD 0.46 Å
- 5F34 chain D against the predicted model A0QWG5: TM-score 0.99, RMSD 0.46 Å
- 5F34 chain B against the predicted model A0QWG5: TM-score 0.99, RMSD 0.47 Å
- 5F34 chain B against the predicted model A0QWG5: TM-score 0.99, RMSD 0.47 Å
- 7OJT chain B against the predicted model A0QWG5: TM-score 0.99, RMSD 0.49 Å
- 7OJT chain B against the predicted model A0QWG5: TM-score 0.99, RMSD 0.49 Å
Elsewhere
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