UniProt A0Q7Q2
CRISPR-associated endonuclease Cas12a (A0Q7Q2)
CRISPR-associated endonuclease Cas12a (UniProt A0Q7Q2), EC 3.1.-.-, 3.1.21.1: 21 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 137 pockets. Binding sites, druggability and experiment against…
- UniProt
- A0Q7Q2
- Protein
- CRISPR-associated endonuclease Cas12a
- EC
- 3.1.-.-, 3.1.21.1, 3.1.27.2, 4.6.1.22
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 137 · 7 records with a druggable one
Structures
22 records of A0Q7Q2 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5MGA | Structure of the Cpf1 endonuclease R-loop complex after DNA cleavage | x-ray diffraction | A | MG | — |
| 5MGA | Structure of the CPF1 endonuclease R-loop complex after DNA cleavage | x-ray diffraction | A | MG | — |
| 5NFV | Crystal structure of catalytically inactive FnCas12 mutant bound to an R-loop structure containing… | x-ray diffraction | A | MG | 20 (best 0.78) |
| 5NFV | Crystal structure of catalytically inactive FNCAS12 mutant bound to an R-loop structure containing… | x-ray diffraction | A | MG | — |
| 5NG6 | Crystal structure of FnCas12a bound to a crRNA | x-ray diffraction | A, C, E, G | MG | 20 (best 0.77) |
| 5NG6 | Crystal structure of FNCAS12A bound to a crrna | x-ray diffraction | A, C, E, G | MG | — |
| 6GTC | Transition state structure of Cpf1(Cas12a) I1 conformation | electron microscopy | A | — | 20 (best 0.84) |
| 6GTC | Transition state structure of CPF1(CAS12A) I1 conformation | electron microscopy | A | — | — |
| 6GTD | Transient state structure of CRISPR-Cpf1 (Cas12a) I2 conformation | electron microscopy | A | — | 17 (best 0.71) |
| 6GTD | Transient state structure of CRISPR-CPF1 (CAS12A) I2 conformation | electron microscopy | A | — | — |
| 6GTE | Transient state structure of CRISPR-Cpf1 (Cas12a) I3 conformation | electron microscopy | A | — | — |
| 6GTE | Transient state structure of CRISPR-CPF1 (CAS12A) I3 conformation | electron microscopy | A | — | — |
| 6GTF | Transient state structure of CRISPR-Cpf1 (Cas12a) I5 conformation | electron microscopy | A | — | — |
| 6GTF | Transient state structure of CRISPR-CPF1 (CAS12A) I5 conformation | electron microscopy | A | — | — |
| 6GTG | Transition state structure of Cpf1(Cas12a) I4 conformation | electron microscopy | A | MG | — |
| 6GTG | Transition state structure of CPF1(CAS12A) I4 conformation | electron microscopy | A | MG | — |
| 6I1K | Crystal structure of catalytically inactive FNCAS12A in complex with a crrna guide and a dsdna… | x-ray diffraction | A | MG | — |
| 6I1L | Crystal structure of FnCas12a in complex with a crRNA guide and ssDNA target | x-ray diffraction | A, D | MG, K | 20 (best 0.79) |
| 6I1L | Crystal structure of FNCAS12A in complex with a crrna guide and ssdna target | x-ray diffraction | A, D | MG, K | — |
| 8Y0B | Crystal structure of FnCas12a in complex with pre-crRNA and 12nt target DNA | x-ray diffraction | A | MG | 20 (best 0.82) |
| 8Y0C | Crystal structure of FnCas12a in complex with pre-crRNA and 18nt target DNA | x-ray diffraction | A | MG | 20 (best 0.82) |
| A0Q7Q2 | AlphaFold monomer V2.0 prediction for CRISPR-associated endonuclease CAS12A (A0Q7Q2) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6I1L chain D against the predicted model A0Q7Q2: TM-score 0.99, RMSD 1.16 Å
- 6I1L chain D against the predicted model A0Q7Q2: TM-score 0.99, RMSD 1.16 Å
- 8Y0C chain A against the predicted model A0Q7Q2: TM-score 0.97, RMSD 1.99 Å
- 8Y0B chain A against the predicted model A0Q7Q2: TM-score 0.97, RMSD 1.98 Å
- 5MGA chain A against the predicted model A0Q7Q2: TM-score 0.96, RMSD 2.19 Å
- 5MGA chain A against the predicted model A0Q7Q2: TM-score 0.96, RMSD 2.19 Å
- 5NFV chain A against the predicted model A0Q7Q2: TM-score 0.96, RMSD 2.39 Å
- 5NFV chain A against the predicted model A0Q7Q2: TM-score 0.96, RMSD 2.39 Å
- 6I1L chain A against the predicted model A0Q7Q2: TM-score 0.96, RMSD 2.57 Å
- 6I1L chain A against the predicted model A0Q7Q2: TM-score 0.96, RMSD 2.57 Å
Elsewhere
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