UniProt A0A7M4DUC2
DNA-directed RNA polymerase subunit (A0A7M4DUC2)
DNA-directed RNA polymerase subunit (UniProt A0A7M4DUC2), EC 2.7.7.6: 23 experimental structures on GenesisL1, 2 ligands bound, 255 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A0A7M4DUC2
- Protein
- DNA-directed RNA polymerase subunit
- EC
- 2.7.7.6
- Experimental structures
- 23
- Predicted models
- 0
- Ligands
- 2
- Pockets
- 255 · 23 records with a druggable one
Structures
23 records of A0A7M4DUC2 in the MolNFT archive: 23 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7PKS | Structural basis of Integrator-mediated transcription regulation | electron microscopy | A | MG, ZN | 9 (best 0.87) |
| 7UNC | Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome | electron microscopy | A | ZN, MG | 12 (best 0.88) |
| 7UND | Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38) | electron microscopy | A | ZN, MG | 10 (best 0.88) |
| 8A3Y | Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex | electron microscopy | A | ZN, MG | 11 (best 0.88) |
| 8A40 | Structure of mammalian Pol II-TFIIS elongation complex | electron microscopy | A | ZN, MG | 16 (best 0.89) |
| 8B3D | Structure of the Pol II-TCR-ELOF1 complex. | electron microscopy | A | ZN, MG | 12 (best 0.90) |
| 8B3F | Pol II-CSB-CSA-DDB1-ELOF1 | electron microscopy | A | ZN, MG | 12 (best 0.88) |
| 8BVW | RNA polymerase II pre-initiation complex with the distal +1 nucleosome (PIC-Nuc18W) | electron microscopy | A | ZN, MG | 6 (best 0.88) |
| 8BYQ | RNA polymerase II pre-initiation complex with the proximal +1 nucleosome (PIC-Nuc10W) | electron microscopy | A | ZN, MG | 6 (best 0.89) |
| 8P4A | Structural insights into human co-transcriptional capping - structure 1 | electron microscopy | A | MG, ZN | 16 (best 0.85) |
| 8RBX | Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex | electron microscopy | A, Y | ZN, MG | 6 (best 0.88) |
| 8S51 | RNA polymerase II core initially transcribing complex with an ordered RNA of 8 nt | electron microscopy | A | ZN, MG | 12 (best 0.85) |
| 8S52 | RNA polymerase II core initially transcribing complex with an ordered RNA of 10 nt | electron microscopy | A | ZN, MG | 9 (best 0.87) |
| 8S54 | RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state b (composite structure) | electron microscopy | A | ZN, MG | 14 (best 0.86) |
| 8S55 | RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state a (composite structure) | electron microscopy | A | ZN, MG | 14 (best 0.87) |
| 8S5N | RNA polymerase II core initially transcribing complex with an ordered RNA of 12 nt | electron microscopy | A | ZN, MG | 12 (best 0.88) |
| 9BZ0 | Structure of an STK19-containing TC-NER complex | electron microscopy | A | ZN, MG | 9 (best 0.88) |
| 9EGX | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27 | electron microscopy | A | ZN, MG | 12 (best 0.89) |
| 9EGY | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27 | electron microscopy | A | ZN, MG | 10 (best 0.88) |
| 9EGZ | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27 | electron microscopy | A | ZN, MG | 10 (best 0.86) |
| 9EH0 | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, 30 bp upstream | electron microscopy | A | ZN, MG | 12 (best 0.89) |
| 9EH2 | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream | electron microscopy | A | ZN, MG | 12 (best 0.88) |
| 9ER2 | PolII-TCR-STK19 structure. | electron microscopy | A | ZN, MG | 13 (best 0.88) |
Ligands
Elsewhere
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