UniProt A0A140NBS6
ATP-dependent lipid A-core flippase (A0A140NBS6)
ATP-dependent lipid A-core flippase (UniProt A0A140NBS6), EC 7.5.2.6: 4 experimental structures on GenesisL1, 3 ligands bound, 35 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A0A140NBS6
- Protein
- ATP-dependent lipid A-core flippase
- EC
- 7.5.2.6
- Experimental structures
- 4
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 35 · 2 records with a druggable one
Structures
4 records of A0A140NBS6 in the MolNFT archive: 4 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7MEW | E. coli MsbA in complex with G247 | electron microscopy | A, B | Z5Y | 17 (best 0.84) |
| 7MEW | E. COLI msba in complex with G247 | electron microscopy | A, B | Z5Y | — |
| 7SEL | E. coli MsbA in complex with LPS and inhibitor G7090 (compound 3) | x-ray diffraction | A, B | 95X, KDL | 18 (best 0.82) |
| 7SEL | E. COLI msba in complex with lps and inhibitor G7090 (compound 3) | x-ray diffraction | A, B | 95X, KDL | — |
Ligands
- 95X · (2E)-3-{7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1-methylnaphthalen-2-yl}prop-2-enoic acid · in 2 records
- KDL · (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl) ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R}, 5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S}, 4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(o · in 2 records
- Z5Y · (2E)-3-{1-cyclopropyl-7-[(1S)-1-(3,6-dichloro-2-fluorophenyl)ethoxy]naphthalen-2-yl}prop-2-enoic acid · in 2 records
Elsewhere
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