UniProt A0A0F8JXW8
Pyrrolysine--tRNA ligase (A0A0F8JXW8)
Pyrrolysine--tRNA ligase (UniProt A0A0F8JXW8), EC 6.1.1.26: 28 experimental structures on GenesisL1, 22 ligands bound, 56 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A0A0F8JXW8
- Protein
- Pyrrolysine--tRNA ligase
- EC
- 6.1.1.26
- Experimental structures
- 28
- Predicted models
- 0
- Ligands
- 22
- Pockets
- 56 · 16 records with a druggable one
Structures
28 records of A0A0F8JXW8 in the MolNFT archive: 28 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6AAZ | Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with pNO2ZLys | x-ray diffraction | A | MG, ATP, 9UC, K | 2 (best 0.79) |
| 6AAZ | Crystal structure of methanosarcina mazei PYLRS(Y306A/Y384F) complexed with PNO2ZLYS | x-ray diffraction | A | MG, ATP, K | — |
| 6AB0 | Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with pAmPyLys | x-ray diffraction | A | MG, ATP, 9UF, K, PO4 | 3 (best 0.80) |
| 6AB0 | Crystal structure of methanosarcina mazei PYLRS(Y306A/Y384F) complexed with pampylys | x-ray diffraction | A | MG, ATP, K, PO4 | — |
| 6AB1 | Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with oAzZLys | x-ray diffraction | A | MG, ATP, 9V0, K | 3 (best 0.79) |
| 6AB1 | Crystal structure of methanosarcina mazei PYLRS(Y306A/Y384F) complexed with oazzlys | x-ray diffraction | A | MG, ATP, K | — |
| 6AB8 | Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with ZLys | x-ray diffraction | A | MG, ATP, 9VC, K | 2 (best 0.78) |
| 6AB8 | Crystal structure of methanosarcina mazei PYLRS(Y306A/Y384F) complexed with zlys | x-ray diffraction | A | MG, ATP, K | — |
| 6ABK | Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with TeocLys | x-ray diffraction | A | MG, ATP, 9VF | 2 (best 0.79) |
| 6ABK | Crystal structure of methanosarcina mazei PYLRS(Y306A/Y384F) complexed with teoclys | x-ray diffraction | A | MG, ATP | — |
| 6LY3 | PylRS C-terminus domain mutant bound with 3-Benzothienyl-L-alanine and AMPNP | x-ray diffraction | A | ANP, MG, 4OG | 3 (best 0.69) |
| 6LY3 | Pylrs C-terminus domain mutant bound with 3-benzothienyl-L-alanine and ampnp | x-ray diffraction | A | ANP, MG | — |
| 6LY6 | PylRS C-terminus domain mutant bound with 3-(1-Naphthyl)-L-alanine and AMPNP | x-ray diffraction | A | ANP, MG, ALN | 3 (best 0.67) |
| 6LY6 | Pylrs C-terminus domain mutant bound with 3-(1-naphthyl)-L-alanine and ampnp | x-ray diffraction | A | ANP, MG | — |
| 6LY7 | PylRS C-terminus domain mutant bound with 1-Formyl-L-tryptophan and AMPNP | x-ray diffraction | A | ANP, MG, TRF | 2 (best 0.67) |
| 6LY7 | Pylrs C-terminus domain mutant bound with 1-formyl-L-tryptophan and ampnp | x-ray diffraction | A | ANP, MG | — |
| 6LYA | PylRS C-terminus domain mutant bound with 1-Methyl-L-tryptophan and AMPNP | x-ray diffraction | A | ANP, MG | — |
| 6LYA | Pylrs C-terminus domain mutant bound with 1-methyl-L-tryptophan and ampnp | x-ray diffraction | A | ANP, MG, EXL | — |
| 6LYB | PylRS C-terminus domain mutant in complex with 3-Benzothienyl-D-alanine and AMPNP | x-ray diffraction | A | ANP, MG, EXR | 3 (best 0.69) |
| 6LYB | Pylrs C-terminus domain mutant in complex with 3-benzothienyl-D- alanine and ampnp | x-ray diffraction | A | ANP, MG | — |
| 7RSM | Crystal structure of pyrrolysyl-tRNA synthetase (N346D/C348S/Y384F) in complex with… | x-ray diffraction | A, B, C, D | ANP, 2L5 | 16 (best 0.69) |
| 7RSM | Crystal structure of pyrrolysyl-tRNA synthetase (N346D/C348S/Y384F) in complex with… | x-ray diffraction | A, B, C, D | ANP, 2L5 | — |
| 8KE1 | PylRS C-terminus domain mutant bound with L-3-bromophenylalanine and AMPNP | x-ray diffraction | A | ANP, 6CV, MG | 4 (best 0.69) |
| 8KE2 | PylRS C-terminus domain mutant bound with L-3-trifluoromethylphenylalanine and AMPNP | x-ray diffraction | A | MG, ANP, FX9 | 3 (best 0.68) |
| 8KE3 | PylRS C-terminus domain mutant bound with D-3-trifluoromethylphenylalanine and AMPNP | x-ray diffraction | A | ANP, MG, FXC | 3 (best 0.68) |
| 8KE4 | PylRS C-terminus domain mutant bound with D-3-bromophenylalanine and AMPNP | x-ray diffraction | A | ANP, MG, FXF | 2 (best 0.69) |
| 8KE5 | PylRS C-terminus domain mutant bound with D-3-chlorophenylalanine and AMPNP | x-ray diffraction | A | MG, ANP, FXL | 3 (best 0.68) |
| 8KE6 | PylRS C-terminus domain mutant bound with L-3-chlorophenylalanine and AMPNP | x-ray diffraction | A | ANP, MG, FCL | 2 (best 0.70) |
Ligands
- MG · Magnesium ion · in 26 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 18 records
- ATP · Adenosine-5'-triphosphate · in 10 records
- K · Potassium ion · in 8 records
- 2L5 · 2-chloro-L-phenylalanine · in 2 records
- PO4 · Phosphate ion · in 2 records
- 4OG · 3-(1-benzothiophen-3-yl)-L-alanine · in 1 record
- 6CV · 3-bromo-L-phenylalanine · in 1 record
- 9UC · N6-{[(4-nitrophenyl)methoxy]carbonyl}-L-lysine · in 1 record
- 9UF · N6-{[(6-aminopyridin-3-yl)methoxy]carbonyl}-L-lysine · in 1 record
- 9V0 · (2S)-2-azanyl-6-[(2-azidophenyl)methoxycarbonylamino]hexanoic acid · in 1 record
- 9VC · (2S)-2-azanyl-6-(phenylmethoxycarbonylamino)hexanoic acid · in 1 record
- 9VF · (2S)-2-azanyl-6-(trimethylsilylmethoxycarbonylamino)hexanoic acid · in 1 record
- ALN · Naphthalen-2-yl-3-alanine · in 1 record
- EXL · 1-methyl-L-tryptophan · in 1 record
- EXR · (2R)-2-azanyl-3-(1-benzothiophen-3-yl)propanoic acid · in 1 record
- FCL · 3-chloro-L-phenylalanine · in 1 record
- FX9 · (2S)-2-azanyl-3-[3-(trifluoromethyl)phenyl]propanoic acid · in 1 record
- FXC · (2R)-2-azanyl-3-[3-(trifluoromethyl)phenyl]propanoic acid · in 1 record
- FXF · (2R)-2-azanyl-3-(3-bromophenyl)propanoic acid · in 1 record
- FXL · (2R)-2-azanyl-3-(3-chlorophenyl)propanoic acid · in 1 record
- TRF · N1-formyl-tryptophan · in 1 record
Elsewhere
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