UniProt A0A045H8W3
Bifunctional ligase/repressor BirA (A0A045H8W3)
Bifunctional ligase/repressor BirA (UniProt A0A045H8W3), EC 6.3.4.15: 20 experimental structures on GenesisL1, 4 ligands bound, 31 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A0A045H8W3
- Protein
- Bifunctional ligase/repressor BirA
- EC
- 6.3.4.15
- Experimental structures
- 20
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 31 · 4 records with a druggable one
Structures
20 records of A0A045H8W3 in the MolNFT archive: 20 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4XTU | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor… | x-ray diffraction | A, B | 44J | 8 (best 0.67) |
| 4XTU | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor… | x-ray diffraction | A, B | — | — |
| 4XTV | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 36… | x-ray diffraction | A, B | 44K | 8 (best 0.66) |
| 4XTV | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 36… | x-ray diffraction | A, B | — | — |
| 4XTW | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 46 with azide in… | x-ray diffraction | A, B | — | — |
| 4XTW | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 46 with azide in… | x-ray diffraction | A, B | — | — |
| 4XTX | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 57 with azide in… | x-ray diffraction | A, B | — | — |
| 4XTX | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 57 with azide in… | x-ray diffraction | A, B | — | — |
| 4XTY | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 63 with Fluorine in… | x-ray diffraction | A, B | 44L | 8 (best 0.63) |
| 4XTY | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 63 with fluorine in… | x-ray diffraction | A, B | — | — |
| 4XTZ | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 69 that has a… | x-ray diffraction | A, B | — | — |
| 4XTZ | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 69 that has a… | x-ray diffraction | A, B | — | — |
| 4XU0 | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 73 that has a… | x-ray diffraction | A, B | — | — |
| 4XU0 | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 73 that has a… | x-ray diffraction | A, B | — | — |
| 4XU1 | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 82 that incorporates… | x-ray diffraction | A, B | — | — |
| 4XU1 | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 82 that incorporates… | x-ray diffraction | A, B | — | — |
| 4XU2 | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 87 with a 3'deoxy… | x-ray diffraction | A, B | 44Q | 7 (best 0.65) |
| 4XU2 | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 87 with a 3'DEOXY… | x-ray diffraction | A, B | — | — |
| 4XU3 | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 90 that has an… | x-ray diffraction | A, B | — | — |
| 4XU3 | Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 90 that has an… | x-ray diffraction | A, B | — | — |
Ligands
- 44J · N-({[(1R,2S,3R,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide · in 1 record
- 44K · N-({[(1R,3S)-3-(6-amino-9H-purin-9-yl)cyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide · in 1 record
- 44L · 2',5'-dideoxy-2'-fluoro-5'-[({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}sulfamoyl)amino]adenosine · in 1 record
- 44Q · 3',5'-dideoxy-5'-[({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}sulfamoyl)amino]adenosine · in 1 record
Elsewhere
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