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Ligand · ZY0

ZY0 · N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-4-ethyl-8-(2-oxopyrrolidin-1-yl)quinoline-6-carboxamide

ZY0, N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-4-ethyl-8-(2-oxopyrrolidin-1-yl)quinoline-6-carboxamide (C34 H35 F3 N4 O3, 604.7 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
ZY0
Formula
C34 H35 F3 N4 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

ZY0 in 2 structures; the first of them:

  • 2WF0 · Human BACE-1 in complex with 4-ethyl-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluo… · ZY0 A2000 · binds GLY72, GLN73, GLY74, LEU91, ASP93, GLY95, SER96, VAL130 and 19 more
  • 2WF0 · Human bace-1 in complex with 4-ethyl-N-((1S,2R)-2-hydroxy-1… · ZY0 A2000 · binds GLY72, GLN73, GLY74, LEU91, ASP93, GLY95, SER96, VAL130 and 19 more

Residues it binds most

GLY 2, ILE 2, THR 2, ARG 2, ASP 2, GLN 2, SER 2, TYR 2, ASN 2, LEU 2 (residue and the binding sites it lines).

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