Ligand · ZR7

ZR7 · N-{3-[(4ar,7as)-2-amino-6-(5-fluoropyrimidin-2-yl)-4A, 5,6,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7A(4H)-yl]-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide

ZR7, N-{3-[(4ar,7as)-2-amino-6-(5-fluoropyrimidin-2-yl)-4A, 5,6,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7A(4H)-yl]-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide (C22 H20 F2 N8 O2 S, 498.5 g/mol), in the MolNFT structures on GenesisL1…

Component: ZR7
Formula: C22 H20 F2 N8 O2 S
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

ZR7 in 2 structures; the first of them:

7MYU · BACE-1 in complex with compound #22 · ZR7 A401 · binds LYS9, SER10, GLY11, GLN12, GLY13, TYR14, LEU30, ASP32 and 16 more
7MYU · Bace-1 in complex with compound #22 · ZR7 A401 · binds LYS9, SER10, GLY11, GLN12, GLY13, TYR14, LEU30, ASP32 and 16 more

Residues it binds most

GLY 4, ILE 4, SER 4, ASP 4, THR 4, TYR 4, ALA 4, ARG 4, GLN 4, LEU 4 (residue and the binding sites it lines).

Found with

SO4 · Sulfate ion

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