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Ligand · ZP4

ZP4 · [[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl] [(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methyl hydrogen phosphate

ZP4, [[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl] [(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methyl hydrogen phosphate…

Component
ZP4
Formula
C20 H28 N10 O19 P4
Class
ligand
Structures
4
PDB entries
2

Binding sites

ZP4 in 4 structures; the first of them:

  • 3KLE · Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to a DSDNA… · ZP4 A823 · binds GLU44, LYS65, ARG70, ARG72, ASP110, VAL111, GLY112, ASP113 and 11 more
  • 3KLF · Crystal structure of wild-type HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a… · ZP4 A823 · binds LYS65, ARG72, ASP110, VAL111, GLY112, ASP113, ALA114, TYR115 and 10 more
  • 3KLE · Crystal structure of azt-resistant HIV-1 reverse transcriptase crosslinked to a dsdna… · ZP4 A823 · binds GLU44, LYS65, ARG70, ARG72, ASP110, VAL111, GLY112, ASP113 and 11 more
  • 3KLF · Crystal structure of wild-type HIV-1 reverse transcriptase crosslinked to a dsdna with a… · ZP4 A823 · binds LYS65, ARG72, ASP110, VAL111, GLY112, ASP113, ALA114, TYR115 and 10 more

Residues it binds most

ASP 16, LYS 16, ARG 16, GLN 16, TYR 16, 2DA 16, ALA 16, DA 16, GLY 16, PHE 16 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • GOL · Glycerol
  • GLC · alpha-D-glucopyranose
  • Z9N · alpha-D-fructofuranose

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