Ligand · ZNM

ZNM · 3-[(1R,3R)-1-(2,6-difluoro-4-{[1-(3-fluoropropyl) azetidin-3-yl]amino}phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl]-2,2-difluoropropan-1-ol

ZNM, 3-[(1R,3R)-1-(2,6-difluoro-4-{[1-(3-fluoropropyl) azetidin-3-yl]amino}phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl]-2,2-difluoropropan-1-ol (C27 H31 F5 N4 O, 522.6 g/mol), in the MolNFT structures on GenesisL1: bound…

Component: ZNM
Formula: C27 H31 F5 N4 O
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

ZNM in 2 structures; the first of them:

7MSA · GDC-9545 in complex with estrogen receptor alpha · ZNM A601 · binds MET343, LEU346, THR347, LEU349, ALA350, ASP351, GLU353, LEU354 and 15 more
7MSA · Gdc-9545 in complex with estrogen receptor alpha · ZNM A601 · binds MET343, LEU346, THR347, LEU349, ALA350, ASP351, GLU353, LEU354 and 15 more

Residues it binds most

LEU 4, MET 4, PHE 4, ALA 4, ARG 4, ASP 4, GLU 4, GLY 4, HIS 4, ILE 4 (residue and the binding sites it lines).

Found with

G9J · (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol

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