ZMS · N,N'-{oxybis[(ethane-2,1-diyl)oxy(1-oxoethane-2,1-diyl)piperidine-1,4-diyl]}bis{4-[(4-{4-chloro-3-[(2-methylpropane-2-sulfonyl)amino]anilino}-5-methylpyrimidin-2-yl)amino]-2-fluorobenzamide}

Binding sites

ZMS in 3 structures; the first of them:

• 7MR5 · Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-052 · ZMS A201 · binds GLN78, PHE79, TRP81, PRO82, PHE83, VAL87, LEU92, LEU94 and 24 more
• 7MR5 · Crystal structure of the first bromodomain (BD1) of human BRD4 bound to gxh-II-052 · ZMS A201 · binds GLN78, PHE79, TRP81, PRO82, PHE83, VAL87, LEU92, LEU94 and 20 more
• 7MRC · Crystal structure of the first bromodomain (BD1) of human brdt bound to gxh-II-052 · ZMS B201 · binds PHE48, TRP50, PRO51, PHE52, VAL56, LYS60, LEU61, GLN62 and 20 more

Residues it binds most

LEU 3, PHE 3, VAL 3, ASN 3, PRO 3, TYR 3, ASP 3, GLN 3, ILE 3, TRP 3 (residue and the binding sites it lines).

Found with

• EDO · 1,2-ethanediol
• DMS · Dimethyl sulfoxide