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Ligand · ZMM

ZMM · 2-methyl-4-[3-(2-oxopyrrolidin-1-yl)phenyl]isoquinolin-1(2H)-one

ZMM, 2-methyl-4-[3-(2-oxopyrrolidin-1-yl)phenyl]isoquinolin-1(2H)-one (C20 H18 N2 O2, 318.4 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues…

Component
ZMM
Formula
C20 H18 N2 O2
Class
ligand
Structures
3
PDB entries
2

Binding sites

ZMM in 3 structures; the first of them:

  • 7MR9 · Crystal structure of the first bromodomain (BD1) of human BRD4 bound to NC-II-153 · ZMM A201 · binds TRP81, PRO82, PHE83, GLN85, PRO86, VAL87, ASP88, LEU92 and 6 more
  • 7MR9 · Crystal structure of the first bromodomain (BD1) of human BRD4 bound to nc-II-153 · ZMM A201 · binds TRP81, PRO82, PHE83, GLN85, PRO86, VAL87, ASP88, LEU92 and 4 more
  • 7MRG · Crystal structure of the first bromodomain (BD1) of human brdt bound to nc-II-153 · ZMM A201 · binds TRP50, PRO51, PHE52, PRO55, VAL56, ASP57, LEU61, LEU63 and 3 more

Residues it binds most

LEU 4, PRO 4, ASN 4, ASP 4, ILE 4, PHE 4, TRP 4, VAL 4, CYS 3, TYR 2 (residue and the binding sites it lines).

Found with

  • EDO · 1,2-ethanediol
  • CL · Chloride ion

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