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Ligand · ZGS

ZGS · [(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$L^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] (9~{Z},12~{Z}, 15~{Z})-octadeca-9,12,15-trienoate

ZGS, [(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$L^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] (9~{Z},12~{Z}, 15~{Z})-octadeca-9,12,15-trienoate (C26 H49 N O7 P +1, 518.6 g/mol), in the MolNFT structures on GenesisL1: bound in 7 records (6…

Component
ZGS
Formula
C26 H49 N O7 P +1
Class
ligand
Structures
7
PDB entries
6

Binding sites

ZGS in 7 structures; the first of them:

  • 7MJS · Single-Particle Cryo-EM Structure of Major Facilitator Superfamily Domain containing 2A… · ZGS X601 · binds GLN52, PHE60, ALA179, MET182, THR183, VAL186, PHE308, LEU311 and 9 more
  • 8D2S · Zebrafish MFSD2A isoform B in inward open ligand bound conformation · ZGS A601 · binds TYR50, GLN51, PHE59, ARG84, ASP87, GLU184, PHE305, MET306 and 18 more
  • 8D2U · Zebrafish MFSD2A isoform B in inward open ligand 1A conformation · ZGS A601 · binds TYR50, GLN51, GLY54, ILE57, PHE59, ARG84, ASP87, TYR145 and 17 more
  • 8D2V · Zebrafish MFSD2A isoform B in inward open ligand 1B conformation · ZGS A601 · binds GLN51, CYS55, PHE59, ARG180, MET181, GLU184, VAL185, PHE305 and 13 more
  • 8D2W · Zebrafish MFSD2A isoform B in inward open ligand 2B conformation · ZGS A601 · binds MET164, GLN170, ARG173, ASP174, THR177, ARG180, MET181, GLU184 and 14 more
  • 8D2X · Zebrafish MFSD2A isoform B in inward open ligand 3C conformation · ZGS A601 · binds MET181, THR182, VAL185, LEU186, THR338, ILE341, GLN345, LEU397 and 3 more
  • 7MJS · Single-particle cryo-EM structure of major facilitator superfamily domain containing 2A… · ZGS X601 · binds PHE60, MET182, THR183, VAL186, PHE308, GLU312, MET337, ILE344 and 5 more

Residues it binds most

PHE 7, VAL 9, LEU 9, MET 9, THR 8, GLU 8, GLN 8, ILE 9, ALA 6, TRP 8 (residue and the binding sites it lines).

Found with

  • LMT · Dodecyl-beta-D-maltoside
  • NA · Sodium ion
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose

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