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Ligand · ZGA

ZGA · Zaragozic acid A

ZGA, Zaragozic acid A (C35 H46 O14, 690.7 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
ZGA
Formula
C35 H46 O14
Class
ligand
Structures
4
PDB entries
2

Binding sites

ZGA in 4 structures; the first of them:

  • 3VJC · Crystal structure of the human squalene synthase in complex with zaragozic acid A · ZGA A400 · binds THR50, SER51, ARG52, SER53, PHE54, ILE58, VAL69, PHE72 and 20 more
  • 3VJE · Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from… · ZGA A301 · binds HIS18, SER19, LYS20, SER21, PHE22, ALA25, PHE26, VAL37 and 17 more
  • 3VJC · Crystal structure of the human squalene synthase in complex with zaragozic acid a · ZGA A400 · binds THR50, SER51, ARG52, SER53, PHE54, ILE58, VAL69, PHE72 and 20 more
  • 3VJE · Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from… · ZGA A301 · binds HIS18, SER19, LYS20, SER21, PHE22, ALA25, PHE26, VAL37 and 17 more

Residues it binds most

VAL 16, ARG 16, LEU 16, PHE 16, THR 12, MET 12, SER 16, ILE 16, ASP 16, ALA 16 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • PO4 · Phosphate ion

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