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Ligand · ZES

ZES · [3-(4-bromo-2-fluoro-benzyl)-7-chloro-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetic acid

ZES, [3-(4-bromo-2-fluoro-benzyl)-7-chloro-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetic acid (C17 H11 Br Cl F N2 O4, 441.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
ZES
Formula
C17 H11 Br Cl F N2 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

ZES in 2 structures; the first of them:

  • 1IEI · Crystal structure of human aldose reductase complexed with the inhibitor zenarestat. · ZES A351 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, THR113, PHE122 and 6 more
  • 1IEI · Crystal structure of human aldose reductase complexed with the inhibitor zenarestat. · ZES A351 · binds TRP20, VAL47, TYR48, TRP79, HIS110, TRP111, THR113, PHE122 and 6 more

Residues it binds most

TRP 2, CYS 2, TYR 2, ALA 2, HIS 2, LEU 2, PHE 2, THR 2, VAL 2 (residue and the binding sites it lines).

Found with

  • NAP · Nadp nicotinamide-adenine-dinucleotide phosphate

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