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Ligand · Z3A

Z3A · 4-{[(2R,3R)-1,3-dihydroxybutan-2-yl]amino}-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide

Z3A, 4-{[(2R,3R)-1,3-dihydroxybutan-2-yl]amino}-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide (C18 H20 N4 O3, 340.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues…

Component
Z3A
Formula
C18 H20 N4 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

Z3A in 2 structures; the first of them:

  • 6NY4 · Crystal structure of JAK3 kinase domain in complex with a pyrrolopyridazine carboxamide… · Z3A A4000 · binds LEU828, GLY829, VAL836, ALA853, VAL884, MET902, GLU903, TYR904 and 9 more
  • 6NY4 · Crystal structure of JAK3 kinase domain in complex with a pyrrolopyridazine carboxamide… · Z3A A4000 · binds LEU828, GLY829, VAL836, ALA853, VAL884, MET902, GLU903, TYR904 and 8 more

Residues it binds most

LEU 2, ALA 2, GLY 2, VAL 2, ARG 2, ASN 2, ASP 2, GLU 2, MET 2, PRO 2 (residue and the binding sites it lines).

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