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Ligand · YRM

YRM · (5S)-6,6-dimethyl-8-[(4S)-7-(trifluoromethyl)imidazo[1, 5-a]pyridin-5-yl]-1,3,8-triazaspiro[4.5]decane-2,4-dione

YRM, (5S)-6,6-dimethyl-8-[(4S)-7-(trifluoromethyl)imidazo[1, 5-a]pyridin-5-yl]-1,3,8-triazaspiro[4.5]decane-2,4-dione (C17 H18 F3 N5 O2, 381.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component
YRM
Formula
C17 H18 F3 N5 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

YRM in 2 structures; the first of them:

  • 7M7D · Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with IACS-8968 · YRM A501 · binds TYR126, CYS129, VAL130, PHE163, PHE164, PHE226, ARG231, LEU234 and 6 more
  • 7M7D · Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with iacs-8968 · YRM A501 · binds TYR126, CYS129, VAL130, PHE163, PHE164, PHE226, ARG231, LEU234 and 6 more

Residues it binds most

PHE 4, LEU 4, SER 4, VAL 4, ALA 4, ARG 4, CYS 4, GLY 4, ILE 4, TYR 4 (residue and the binding sites it lines).

Found with

  • HEM · Protoporphyrin IX containing Fe

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