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Ligand · YG4

YG4 · [(2~{R},3~{R},4~{R},5~{R})-5-(6-azanyl-7,8-dihydropurin-9-yl)-2-[[[[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1,8-dihydropurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-4-methoxy-oxolan-3-yl] [(2~{R}, 3~{S},4~{R},5~{S})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate

YG4, [(2~{R},3~{R},4~{R},5~{R})-5-(6-azanyl-7,8-dihydropurin-9-yl)-2-[[[[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1,8-dihydropurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl…

Component
YG4
Formula
C31 H46 N12 O25 P4
Class
ligand
Structures
3
PDB entries
2

Binding sites

YG4 in 3 structures; the first of them:

  • 7LW3 · Structure of SARS-CoV-2 nsp16/nsp10 complex in presence of Cap-1 analog (m7GpppAmU) and… · YG4 A704 · binds CYS25, ASP26, LEU27, TYR30, ASN43, LYS46, ASP75, ASP130 and 11 more
  • 8JCE · Cryo-EM Structure of Chikungunya Virus Nonstructural Protein 1 with m7GpppAmU · YG4 A1003 · binds ASP7, THR33, PRO34, ASN35, ALA37, ALA40, ARG41, SER44 and 18 more
  • 7LW3 · Structure of SARS-cov-2 NSP16/NSP10 complex in presence of cap-1 analog (M7GPPPAMU) and… · YG4 A704 · binds CYS25, ASP26, LEU27, TYR30, ASN43, LYS46, ASP75, ASP130 and 11 more

Residues it binds most

ARG 12, ASP 14, TYR 14, ASN 14, GLU 14, THR 14, ALA 12, VAL 12, LYS 14, SER 14 (residue and the binding sites it lines).

Found with

  • SAH · S-adenosyl-L-homocysteine
  • MG · Magnesium ion
  • ZN · Zinc ion
  • EDO · 1,2-ethanediol
  • MES · 2-(N-morpholino)-ethanesulfonic acid

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