GL1X · GenesisL1 explorer

Ligand · X6M

X6M · N-(6-fluoro-3'-{[6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carbonyl]amino}-4'-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-carbonyl) glycyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-{(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl}-L-prolinamide

X6M, N-(6-fluoro-3'-{[6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carbonyl]amino}-4'-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-carbonyl)…

Component
X6M
Formula
C52 H59 F4 N9 O7 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

X6M in 2 structures; the first of them:

  • 7JTP · Crystal structure of Protac MS67 in complex with the WD repeat-containing protein 5 and… · X6M A402 · binds ASN67, ARG69, PHE76, PRO86, TRP88, PHE91, TYR98, PRO99 and 30 more
  • 7JTP · Crystal structure of protac MS67 in complex with the wd repeat- containing protein 5 and… · X6M A402 · binds ARG69, PHE76, TRP88, PHE91, TYR98, PRO99, ARG107, ILE109 and 25 more

Residues it binds most

PHE 2, SER 2, TYR 2, ASP 2, ILE 2, PRO 2, ARG 2, CYS 2, HIS 2, TRP 2 (residue and the binding sites it lines).

Found with

  • GOL · Glycerol

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