Ligand · X4G

X4G · (3R)-1-{[1-(5-fluoro-2-{[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]amino}pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl]methyl}pyrrolidin-3-ol

X4G, (3R)-1-{[1-(5-fluoro-2-{[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]amino}pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl]methyl}pyrrolidin-3-ol (C24 H30 F N5 O3, 455.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component: X4G
Formula: C24 H30 F N5 O3
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

X4G in 2 structures; the first of them:

4XG4 · Crystal structure of an inhibitor-bound Syk · X4G A701 · binds LEU377, VAL385, ALA400, LYS402, GLU420, VAL433, MET448, GLU449 and 10 more
4XG4 · Crystal structure of an inhibitor-bound syk · X4G A701 · binds LEU377, VAL385, ALA400, LYS402, GLU420, VAL433, MET448, GLU449 and 10 more

Residues it binds most

GLU 2, LEU 2, ALA 2, MET 2, VAL 2, ARG 2, ASN 2, ASP 2, GLY 2, LYS 2 (residue and the binding sites it lines).

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