X3N · N~2~-{(4S,11aP)-2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-L-alaninamide

Binding sites

X3N in 3 structures; the first of them:

• 8EXV · Crystal structure of PI3K-alpha in complex with compound 32 · X3N A1101 · binds ARG770, MET772, SER774, PRO778, TRP780, ILE800, LYS802, ASP810 and 12 more
• 8TDU · STX-478, a Mutant-Selective, Allosteric Inhibitor bound to PI3Kalpha · X3N A1101 · binds ARG770, MET772, SER774, PRO778, TRP780, ILE800, LYS802, ASP810 and 12 more
• 8TGD · STX-478, a Mutant-Selective, Allosteric Inhibitor bound to H1047R PI3Kalpha · X3N A1511 · binds ARG770, MET772, SER774, PRO778, TRP780, ILE800, LYS802, ASP810 and 12 more

Residues it binds most

ILE 5, ASP 5, MET 5, SER 5, VAL 5, ARG 5, GLN 5, GLU 5, HIS 5, LYS 5 (residue and the binding sites it lines).

Found with

• ZWE · N-(2-aminopyrimidin-5-yl)-N'-[(1R)-1-(5,7-difluoro-3-methyl-1-benzofuran-2-yl)-2,2,2-trifluoroethyl]urea
• EDO · 1,2-ethanediol