Ligand · W2R
W2R · 1-{3-[2-chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5H-pyrrolo[3,2-d]pyrimidin-4-yl}amino)phenoxy]phenyl}-3-cyclohexylurea
W2R, 1-{3-[2-chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5H-pyrrolo[3,2-d]pyrimidin-4-yl}amino)phenoxy]phenyl}-3-cyclohexylurea (C29 H33 Cl N6 O4, 565.1 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every…
- Component
- W2R
- Formula
- C29 H33 Cl N6 O4
- Class
- ligand
- Structures
- 4
- PDB entries
- 2
Binding sites
W2R in 4 structures; the first of them:
- 3W2R · EGFR Kinase domain T790M/L858R mutant with compound 4 · W2R A1101 · binds LEU718, PHE723, VAL726, ALA743, ILE744, LYS745, LEU747, ILE759 and 17 more
- 3W2S · EGFR kinase domain with compound4 · W2R A1101 · binds LEU718, PHE723, VAL726, ALA743, ILE744, LYS745, LEU747, MET766 and 20 more
- 3W2R · EGFR kinase domain T790M/L858R mutant with compound 4 · W2R A1101 · binds LEU718, PHE723, VAL726, ALA743, ILE744, LYS745, LEU747, ILE759 and 17 more
- 3W2S · EGFR kinase domain with COMPOUND4 · W2R A1101 · binds LEU718, PHE723, VAL726, ALA743, ILE744, LYS745, LEU747, MET766 and 20 more
Residues it binds most
LEU 4, MET 4, PHE 4, ILE 4, ALA 4, ARG 4, CYS 4, GLY 4, THR 4, ASN 4 (residue and the binding sites it lines).
Found with
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