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Ligand · VZV

VZV · 1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-6-methyl-3-(propan-2-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-N,N-dimethyl-L-prolinamide

VZV, 1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-6-methyl-3-(propan-2-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-N,N-dimethyl-L-prolinamide (C29 H32 Cl2 N4 O2 S, 571.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records…

Component
VZV
Formula
C29 H32 Cl2 N4 O2 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

VZV in 2 structures; the first of them:

  • 3VZV · Crystal structure of human mdm2 with a dihydroimidazothiazole inhibitor · VZV A200 · binds LEU54, LEU57, GLY58, ILE61, MET62, TYR67, GLN72, HIS73 and 6 more
  • 3VZV · Crystal structure of human MDM2 with a dihydroimidazothiazole inhibitor · VZV A200 · binds LEU54, LEU57, GLY58, ILE61, MET62, TYR67, GLN72, HIS73 and 6 more

Residues it binds most

TYR 4, LEU 4, ILE 4, HIS 4, MET 4, PHE 4, VAL 4, GLN 4, GLY 4, LYS 2 (residue and the binding sites it lines).

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