Ligand · VZ6
VZ6 · 9-[(1~{S},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one
VZ6, 9-[(1~{S},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H…
- Component
- VZ6
- Formula
- C21 H23 F2 N9 O10 P2
- Class
- ligand
- Structures
- 2
- PDB entries
- 2
Binding sites
VZ6 in 2 structures; the first of them:
- 8ORV · Crystal structure of monkeypox virus poxin in complex with the STING agonist MD1203 · VZ6 A201 · binds GLY127, ASN128, ALA129, TYR138, VAL167, GLN169, ARG182, ARG184
- 8ORW · Crystal structure of human STING in complex with the agonist MD1203 · VZ6 A401 · binds SER162, TYR163, GLY166, TYR167, ILE235, ARG238, VAL239, TYR240 and 4 more
Residues it binds most
TYR 2, ARG 2, GLY 2, SER 1, THR 1, VAL 2, ALA 1, ASN 1, GLN 1, ILE 1 (residue and the binding sites it lines).
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