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Ligand · VZ5

VZ5 · (14beta,17alpha)-2-ethyl-17-hydroxyestra-1(10),2,4-trien-3-yl sulfamate

VZ5, (14beta,17alpha)-2-ethyl-17-hydroxyestra-1(10),2,4-trien-3-yl sulfamate (C20 H29 N O4 S, 379.5 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the…

Component
VZ5
Formula
C20 H29 N O4 S
Class
ligand
Structures
4
PDB entries
2

Binding sites

VZ5 in 4 structures; the first of them:

  • 3OIL · Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol… · VZ5 A263 · binds ASN62, HIS64, GLN67, GLN92, HIS94, HIS96, GLU106, HIS119 and 9 more
  • 3OIM · Human Carbonic anhydrase II bound by 2-Ethylestradiol 3-O-sulfamate · VZ5 A263 · binds GLN92, HIS94, HIS96, GLU106, HIS119, VAL121, PHE131, VAL135 and 8 more
  • 3OIL · Human carbonic anhydrase II mutant A65S, N67Q (ca IX mimic) bound by 2-ethylestradiol… · VZ5 A263 · binds ASN62, HIS64, GLN67, GLN92, HIS94, HIS96, GLU106, HIS119 and 9 more
  • 3OIM · Human carbonic anhydrase II bound by 2-ethylestradiol 3-O-sulfamate · VZ5 A263 · binds GLN92, HIS94, HIS96, GLU106, HIS119, VAL121, PHE131, VAL135 and 8 more

Residues it binds most

HIS 4, LEU 4, VAL 4, THR 4, GLN 4, GLU 4, PHE 4, PRO 2, ASN 2, SER 2 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • DMS · Dimethyl sulfoxide
  • GOL · Glycerol

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