GL1X · GenesisL1 explorer

Ligand · VXY

VXY · 2,2-difluoroethyl (3S)-3-{[2'-amino-5-fluoro-2-(morpholin-4-yl)[4,5'-bipyrimidin]-6-yl]amino}-3-(hydroxymethyl)pyrrolidine-1-carboxylate

VXY, 2,2-difluoroethyl (3S)-3-{[2'-amino-5-fluoro-2-(morpholin-4-yl)[4,5'-bipyrimidin]-6-yl]amino}-3-(hydroxymethyl)pyrrolidine-1-carboxylate (C20 H25 F3 N8 O4, 498.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
VXY
Formula
C20 H25 F3 N8 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

VXY in 2 structures; the first of them:

  • 7K6M · Crystal structure of PI3Kalpha selective Inhibitor PF-06843195 · VXY A9001 · binds ARG770, MET772, SER774, PRO778, TRP780, ILE800, LYS802, ASP805 and 17 more
  • 7K6M · Crystal structure of PI3KALPHA selective inhibitor pf-06843195 · VXY A9001 · binds ARG770, MET772, SER774, PRO778, TRP780, ILE800, LYS802, ASP805 and 17 more

Residues it binds most

ASP 2, ILE 2, SER 2, MET 2, PHE 2, VAL 2, ARG 2, GLN 2, GLU 2, HIS 2 (residue and the binding sites it lines).

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.