GL1X · GenesisL1 explorer

Ligand · VFV

VFV · N-[(1R)-1-(3,4'-difluorobiphenyl-4-yl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide

VFV, N-[(1R)-1-(3,4'-difluorobiphenyl-4-yl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide (C32 H23 F2 N5 O2, 547.5 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding…

Component
VFV
Formula
C32 H23 F2 N5 O2
Class
ligand
Structures
6
PDB entries
3

Binding sites

VFV in 6 structures; the first of them:

  • 4G7G · Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the VNI… · VFV A502 · binds PHE48, TYR103, PHE105, MET106, PHE110, ALA115, TYR116, MET123 and 15 more
  • 4UHI · Human sterol 14-alpha demethylase (CYP51) in complex with vfv in C121 space group · VFV A580 · binds VAL130, TYR131, LEU134, THR135, PHE139, ALA144, TYR145, PHE152 and 14 more
  • 4UHL · Human sterol 14-alpha demethylase (CYP51) in complex with vfv in P1 space group · VFV A580 · binds VAL130, TYR131, LEU134, THR135, PHE139, VAL143, ALA144, TYR145 and 15 more
  • 4G7G · Sterol 14-alpha demethylase (CYP51) from trypanosoma brucei in complex with the vni… · VFV A502 · binds PHE48, TYR103, PHE105, MET106, PHE110, ALA115, TYR116, MET123 and 15 more
  • 4UHI · Human sterol 14-alpha demethylase (CYP51) in complex with vfv in C121 space group · VFV A580 · binds VAL130, TYR131, LEU134, THR135, PHE139, ALA144, TYR145, PHE152 and 14 more

Residues it binds most

LEU 56, PHE 56, MET 56, TYR 56, ILE 50, ALA 32, VAL 54, CYS 56, THR 32, HIS 48 (residue and the binding sites it lines).

Found with

  • HEM · Protoporphyrin IX containing Fe

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.