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Ligand · VFM

VFM · 2-methyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl) propanamide

VFM, 2-methyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl) propanamide (C6 H10 N4 O3 S2, 250.3 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it…

Component
VFM
Formula
C6 H10 N4 O3 S2
Class
ligand
Structures
4
PDB entries
2

Binding sites

VFM in 4 structures; the first of them:

  • 7JNW · Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)isobutyramide · VFM A302 · binds ASN67, ILE91, GLN92, HIS94, HIS96, GLU106, HIS119, VAL121 and 7 more
  • 7JO2 · Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)isobutyram… · VFM A302 · binds LEU91, GLN92, HIS94, HIS96, GLU106, HIS119, VAL121, VAL131 and 7 more
  • 7JNW · Carbonic anhydrase II complexed with N-(5-sulfamoyl-1,3,4-thiadiazol- 2-YL)ISOBUTYRAMIDE · VFM A302 · binds ASN67, ILE91, GLN92, HIS94, HIS96, GLU106, HIS119, VAL121 and 7 more
  • 7JO2 · Carbonic anhydrase IX mimic complexed with N-(5-sulfamoyl-1,3,4… · VFM A302 · binds LEU91, GLN92, HIS94, HIS96, GLU106, HIS119, VAL121, VAL131 and 7 more

Residues it binds most

VAL 6, HIS 4, LEU 6, THR 4, GLN 4, GLU 4, ILE 4, PHE 4, SER 4, TRP 4 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • DMS · Dimethyl sulfoxide
  • GOL · Glycerol

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