GL1X · GenesisL1 explorer

Ligand · VAR

VAR · 9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol

VAR, 9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol (C14 H11 N7 O, 293.3 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å…

Component
VAR
Formula
C14 H11 N7 O
Class
ligand
Structures
4
PDB entries
2

Binding sites

VAR in 4 structures; the first of them:

  • 3BHV · Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor variolin B · VAR A299 · binds ILE10, GLY11, GLU12, VAL18, ALA31, LYS33, GLU51, VAL64 and 7 more
  • 4MNB · Crystal Structure of a complex between the marine anticancer drug Variolin B and DNA · VAR A101 · binds DC5, DG6, DG8
  • 3BHV · Structure of phosphorylated THR160 CDK2/CYCLIN a in complex with the inhibitor variolin B · VAR A299 · binds ILE10, GLY11, GLU12, VAL18, ALA31, LYS33, GLU51, VAL64 and 7 more
  • 4MNB · Crystal structure of a complex between the marine anticancer drug variolin B and DNA · VAR A101 · binds DC5, DG6, DG8

Residues it binds most

GLU 4, ALA 4, DG 4, LEU 4, PHE 4, VAL 4, LYS 4, ASP 4, DC 4, GLY 4 (residue and the binding sites it lines).

Found with

  • NCO · Cobalt hexammine(iii)
  • CO · Cobalt (II) ion
  • MG · Magnesium ion
  • NA · Sodium ion
  • SGM · Monothioglycerol

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.