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Ligand · VA8

VA8 · ~{N}-[[(3~{R})-1-[6-(3~{H}-benzimidazol-4-ylmethylamino)pyrimidin-4-yl]-3-oxidanyl-piperidin-3-yl]methyl]-4-[(4,4-dimethylpiperidin-1-yl) methyl]benzamide

VA8, ~{N}-[[(3~{R})-1-[6-(3~{H}-benzimidazol-4-ylmethylamino)pyrimidin-4-yl]-3-oxidanyl-piperidin-3-yl]methyl]-4-[(4,4-dimethylpiperidin-1-yl) methyl]benzamide (C33 H42 N8 O2, 582.8 g/mol), in the MolNFT structures on GenesisL1: bound in 2…

Component
VA8
Formula
C33 H42 N8 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

VA8 in 2 structures; the first of them:

  • 7OEL · Crystal structure of the human METTL3-METTL14 complex with compound UOZ097 · VA8 A601 · binds CYS376, ASP377, ILE378, ARG379, ASP395, PRO396, PRO397, GLY407 and 14 more
  • 7OEL · Crystal structure of the human METTL3-METTL14 complex with compound UOZ097 · VA8 A601 · binds CYS376, ASP377, ILE378, ARG379, ASP395, PRO396, PRO397, GLY407 and 14 more

Residues it binds most

GLY 2, ARG 2, ASP 2, PRO 2, TRP 2, ASN 2, CYS 2, GLN 2, GLU 2, HIS 2 (residue and the binding sites it lines).

Found with

  • ACT · Acetate ion

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