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Ligand · V4M

V4M · 2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide

V4M, 2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide (C22 H18 Cl F2 N3 O4, 461.9 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
V4M
Formula
C22 H18 Cl F2 N3 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

V4M in 2 structures; the first of them:

  • 6XK9 · Cereblon in complex with DDB1, CC-90009, and GSPT1 · V4M Z501 · binds GLN533, VAL535, VAL569, ASP570, LYS571, LYS572, SER573, GLY574 and 17 more
  • 6XK9 · Cereblon in complex with DDB1, cc-90009, and GSPT1 · V4M Z501 · binds GLN533, VAL535, ASP570, LYS571, LYS572, SER573, GLY574, ILE625 and 12 more

Residues it binds most

LYS 4, TRP 4, HIS 4, VAL 3, GLY 4, PHE 4, SER 4, ASN 4, ASP 4, GLN 4 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion

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