GL1X · GenesisL1 explorer

Ligand · UYM

UYM · (3S,6S)-3,6-bis[(1H-indol-3-yl)methyl]piperazine-2,5-dione

UYM, (3S,6S)-3,6-bis[(1H-indol-3-yl)methyl]piperazine-2,5-dione (C22 H20 N4 O2, 372.4 g/mol), in the MolNFT structures on GenesisL1: bound in 5 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the residues it…

Component
UYM
Formula
C22 H20 N4 O2
Class
ligand
Structures
5
PDB entries
4

Binding sites

UYM in 5 structures; the first of them:

  • 6XAK · Crystal structure of NzeB in complex with cyclo-(L-Trp-L-Pro) and cyclo-(L-Trp-L-Trp) · UYM A803 · binds GLN68, LEU80, ARG81, GLY87, ALA89, ILE90, LEU175, GLU232 and 6 more
  • 8YY7 · Crystal structure of PtmB in complex with cyclo-(L-Trp-L-Trp) and Hypoxanthine · UYM A501 · binds LEU76, THR91, ILE92, VAL96, VAL97, ASN99, ALA182, PHE183 and 5 more
  • 8YYP · Crystal structure of PtmB in complex with cyclo-(L-Trp-L-Trp) and Adenine · UYM B503 · binds THR91, ILE92, VAL96, VAL97, ASN99, ALA182, PHE183, SER246 and 4 more
  • 8YZA · Crystal structure of PtmB in complex with cyclo-(L-Trp-L-Trp) and Guanine · UYM A501 · binds LEU76, THR91, ILE92, VAL96, VAL97, ASN99, ALA182, PHE183 and 5 more
  • 6XAK · Crystal structure of nzeb in complex with cyclo-(L-TRP-L-pro) and cyclo-(L-TRP-L-TRP) · UYM A803 · binds GLN68, LEU80, ILE90, GLU232, SER235, LEU236, VAL239, LYS292 and 2 more

Residues it binds most

LEU 7, ALA 6, ILE 8, SER 8, VAL 8, PHE 8, LYS 5, ASN 4, GLN 4, GLU 4 (residue and the binding sites it lines).

Found with

  • HEM · Protoporphyrin IX containing Fe
  • EDO · 1,2-ethanediol
  • ADE · Adenine
  • GUN · Guanine
  • HPA · Hypoxanthine
  • QRP · (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

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