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Ligand · UTH

UTH · 4-((2-(TERT-BUTYL)PHENYL)AMINO)-7-(3,5-dimethylisoxazol-4-yl)-1,8-naphthyridine-3-carboxylic acid

UTH, 4-((2-(TERT-BUTYL)PHENYL)AMINO)-7-(3,5-dimethylisoxazol-4-yl)-1,8-naphthyridine-3-carboxylic acid (C24 H24 N4 O3, 416.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
UTH
Formula
C24 H24 N4 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

UTH in 2 structures; the first of them:

  • 4BW2 · The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand · UTH A1170 · binds TRP81, PRO82, PHE83, VAL87, LEU92, LEU94, TYR97, CYS136 and 5 more
  • 4BW2 · The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand · UTH A1170 · binds TRP81, PRO82, PHE83, VAL87, LEU92, LEU94, TYR97, CYS136 and 5 more

Residues it binds most

LEU 2, TYR 2, ASN 2, ASP 2, CYS 2, ILE 2, MET 2, PHE 2, PRO 2, TRP 2 (residue and the binding sites it lines).

Found with

  • EDO · 1,2-ethanediol

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