GL1X · GenesisL1 explorer

Ligand · UOH

UOH · (2~{R})-2-[5-[5-chloranyl-2-[(2-methyl-1,2,3-triazol-4-yl)amino]pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-1-(3-fluoranyl-5-methoxy-phenyl)-2-oxidanyl-ethyl]propanamide

UOH, (2~{R})-2-[5-[5-chloranyl-2-[(2-methyl-1,2,3-triazol-4-yl)amino]pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-1-(3-fluoranyl-5-methoxy-phenyl)-2-oxidanyl-ethyl]propanamide (C27 H26 Cl F N8 O4, 581.0 g/mol), in the…

Component
UOH
Formula
C27 H26 Cl F N8 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

UOH in 2 structures; the first of them:

  • 7NR5 · Discovery of ASTX029, a clinical candidate which modulates the phosphorylation and… · UOH A405 · binds ILE31, ALA35, TYR36, VAL39, ALA52, LYS54, ILE56, PRO58 and 16 more
  • 7NR5 · Discovery of ASTX029, a clinical candidate which modulates the phosphorylation and… · UOH A405 · binds ILE31, ALA35, TYR36, VAL39, ALA52, LYS54, ILE56, PRO58 and 16 more

Residues it binds most

ILE 2, ALA 2, ASP 2, GLU 2, LEU 2, LYS 2, THR 2, TYR 2, ARG 2, CYS 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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