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Ligand · UC1

UC1 · 2-methyl-furan-3-carbothioic acid [4-chloro-3-(3-methyl-but-2-enyloxy)-phenyl]-amide

UC1, 2-methyl-furan-3-carbothioic acid [4-chloro-3-(3-methyl-but-2-enyloxy)-phenyl]-amide (C17 H18 Cl N O2 S, 335.9 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues…

Component
UC1
Formula
C17 H18 Cl N O2 S
Class
ligand
Structures
8
PDB entries
4

Binding sites

UC1 in 8 structures; the first of them:

  • 1JLG · Crystal structure of Y188C mutant HIV-1 reverse transcriptase in complex with uc-781 · UC1 A999 · binds PRO95, LEU100, LYS101, LYS103, VAL106, VAL179, TYR181, CSD188 and 9 more
  • 1RT4 · HIV-1 reverse transcriptase complexed with UC781 · UC1 A999 · binds PRO95, LEU100, LYS101, LYS103, VAL106, VAL179, ILE180, TYR181 and 10 more
  • 1S1T · Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with UC-781 · UC1 A999 · binds PRO95, ILE100, LYS101, LYS102, LYS103, VAL106, VAL179, TYR181 and 10 more
  • 1S1W · Crystal structure of V106A mutant HIV-1 reverse transcriptase in complex with UC-781 · UC1 A999 · binds PRO95, LEU100, LYS101, LYS102, LYS103, ALA106, VAL179, ILE180 and 11 more
  • 1JLG · Crystal structure of Y188C mutant HIV-1 reverse transcriptase in complex with uc-781 · UC1 A999 · binds PRO95, LEU100, LYS101, LYS103, VAL106, VAL179, TYR181, CSD188 and 9 more
  • 1RT4 · HIV-1 reverse transcriptase complexed with UC781 · UC1 A999 · binds PRO95, LEU100, LYS101, LYS103, VAL106, VAL179, ILE180, TYR181 and 10 more
  • 1S1T · Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with uc-781 · UC1 A999 · binds PRO95, ILE100, LYS101, LYS102, LYS103, VAL106, VAL179, TYR181 and 10 more
  • 1S1W · Crystal structure of V106A mutant HIV-1 reverse transcriptase in complex with uc-781 · UC1 A999 · binds PRO95, LEU100, LYS101, LYS102, LYS103, ALA106, VAL179, ILE180 and 11 more

Residues it binds most

TYR 8, VAL 8, LYS 8, PRO 8, LEU 8, GLU 8, GLY 8, HIS 8, PHE 8, TRP 8 (residue and the binding sites it lines).

Found with

  • PO4 · Phosphate ion

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