Ligand · U8P

U8P · Tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl) azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate

U8P, Tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl) azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate (C27 H30 N8 O4 S, 562.6 g/mol), in the MolNFT structures on GenesisL1: bound in 1 record (1 PDB…

Component: U8P
Formula: C27 H30 N8 O4 S
Class: ligand
Structures: 1
PDB entries: 1

Binding sites

U8P in 1 structure; the first of them:

6WTP · Human JAK2 JH1 domain in complex with protac-intermediate linker handle 3 · U8P A1201 · binds LEU855, GLY856, LYS857, GLY858, GLY861, SER862, VAL863, ALA880 and 13 more

Residues it binds most

GLY 1, LEU 1, ASP 1, LYS 1, ALA 1, ARG 1, ASN 1, GLU 1, MET 1, PRO 1 (residue and the binding sites it lines).

Found with

GOL · Glycerol

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