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Ligand · U35

U35 · (2~{S})-3-methyl-2-[pentanoyl-[[4-[2-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid

U35, (2~{S})-3-methyl-2-[pentanoyl-[[4-[2-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid (C24 H29 N5 O3, 435.5 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (3 PDB entries). Every binding site…

Component
U35
Formula
C24 H29 N5 O3
Class
ligand
Structures
4
PDB entries
3

Binding sites

U35 in 4 structures; the first of them:

  • 7BM1 · Notum_Valsartan complex · U35 A514 · binds TRP128, TYR129, VAL187, ALA233, THR236, PHE268, LEU269, PRO287 and 6 more
  • 8DQT · Human PDK1 kinase domain in complex with Valsartan · U35 A401 · binds VAL124, THR128, GLN150, LEU155
  • 8EGU · Branched chain ketoacid dehydrogenase kinase complexes · U35 A402 · binds LEU68, ILE72, LEU98, TYR99, ALA102, LEU106, VAL125, LEU128 and 11 more
  • 7BM1 · NOTUM_VALSARTAN complex · U35 A514 · binds TRP128, TYR129, VAL187, ALA233, THR236, PHE268, LEU269, PRO287 and 6 more

Residues it binds most

LEU 7, VAL 6, THR 6, ILE 5, ARG 3, PHE 3, TYR 5, ALA 3, PRO 5, GLY 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • DMS · Dimethyl sulfoxide
  • EDO · 1,2-ethanediol
  • ADP · Adenosine-5'-diphosphate
  • GOL · Glycerol

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