GL1X · GenesisL1 explorer

Ligand · U0Q

U0Q · 4-amino-7-methyl-2-[(1-methyl-1H-pyrazol-4-yl)amino]-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

U0Q, 4-amino-7-methyl-2-[(1-methyl-1H-pyrazol-4-yl)amino]-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (C17 H21 N9, 351.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
U0Q
Formula
C17 H21 N9
Class
ligand
Structures
2
PDB entries
1

Binding sites

U0Q in 2 structures; the first of them:

  • 7BJX · Crystal structure of CHK1-10pt-mutant complex with compound 26 · U0Q A301 · binds LEU15, GLY16, GLU17, GLY18, VAL23, ALA36, MET84, GLU85 and 9 more
  • 7BJX · Crystal structure of CHK1-10PT-mutant complex with compound 26 · U0Q A301 · binds LEU15, GLY16, GLU17, GLY18, VAL23, ALA36, MET84, GLU85 and 9 more

Residues it binds most

ALA 4, LEU 4, GLY 4, GLU 4, ASN 4, ASP 4, HIS 4, MET 4, SER 4, VAL 4 (residue and the binding sites it lines).

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